Trial reportTranslational vision science & technology2025
Effect of Repeated Low-Level Red Light Versus 0.01% Topical Atropine on Myopia Progression: A Randomized Crossover-Controlled Trial.
Trial report in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Duration-Dependent Efficacy and Clinical Safety of Repeated Low-Level Red-Light Therapy for Paediatric Myopia: A Systematic Review and Meta-Analysis.Clinical & experimental ophthalmology · 2026Pooled it
- Differences in Posterior Ocular Morphology Following Red Light Therapy Versus 0.01% Atropine for Myopia Control: A Randomized Controlled Trial Analysis.Investigative ophthalmology & visual science · 2026Trial
- Repeated low-intensity red light combined with defocus-incorporated multiple segments (DIMS) spectacles for controlling myopia progression in children.American journal of translational research · 2026Article
- Awareness of Myopia Associated Complications and Perspectives on Myopia Management Among Parents of Children with Myopia in France and the UK.Patient related outcome measures · 2025Article
- Repeated low-level red-light therapy for myopia control: An update on efficacy and safety.Taiwan journal of ophthalmologyReview
- Transient ocular effects of red light exposure in young adults.Journal of optometryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The purpose of this study was to compare the efficacy of repeated low-level red light (RLRL) and 0.01% atropine in controlling the progression of myopia children. Methods: This randomized, single-blind, crossover-controlled trial recruited 91 myopic children aged 6 to 12 years. Participants were randomly allocated to the RLRL-atropine group (n = 46) and the atropine-RLRL group (n = 45), with intermediate washout for 1 month. Primary outcomes included changes in spherical equivalent refraction (SER) and axial length (AL), whereas the secondary outcomes included changes in subfoveal choroidal thickness (SFCT) and subfoveal choroidal vessel volume (SFCVV). Results: The 13-month data analysis involved 45 (97.8%) and 42 (93.3%) children in the RLRL-atropine and the atropine-RLRL groups, respectively. RLRL was more effective than 0.01% atropine, with a mean difference in SER of 0.54 diopter (D; 0.24 ± 0.30 D vs. -0.29 ± 0.38 D, P < 0.001) and a mean difference in AL of 0.24 mm (-0.09 ± 0.14 mm vs. 0.15 ± 0.16 mm, P < 0.001) in period 1, whereas the mean differences in SER and AL were 0.55 D (0.22 ± 0.27 D vs. -0.33 ± 0.27 D, P < 0.001) and 0.22 mm (-0.06 ± 0.13 mm vs. 0.16 ± 0.11 mm, P < 0.001) in period 2, respectively. RLRL showed increased SFCT and SFCVV than 0.01% atropine (all P < 0.001). The change in SFCT from baseline to 3 months was the crucial predictor for the growth in AL at 6 months (P < 0.05). Conclusions: Compared to 0.01% atropine, RLRL demonstrated superior effectiveness in slowing myopic progression and axial elongation in myopia children. Changes in SFCT may predict the retarding effects of RLRL on axial elongation. Translational Relevance: RLRL is an effective alternative treatment for controlling myopia in schoolchildren.
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