Evidence map›Paper›PMID 40266539›Full record

ArticleClinical and experimental nephrology2025

Skin perfusion pressure in lower extremities at haemodialysis initiation is associated with 1-year mortality and cardiovascular disease.

Yoshifumi Hamasaki, Mikie Imafuku, Kana Suzuki, Shutaro Ishii, Ryo Matsuura, Daisuke Yamada, Masaomi Nangaku

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Article in Clinical and experimental nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yoshifumi Hamasaki *Department of Hemodialysis and Apheresis, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan. yhamasaki-tky@umin.ac.jp.ORCID http://orcid.org/0000-0003-1874-1846
Mikie Imafuku *Department of Hemodialysis and Apheresis, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Kana SuzukiDepartment of Hemodialysis and Apheresis, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Shutaro IshiiDepartment of Hemodialysis and Apheresis, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Ryo MatsuuraDepartment of Nephrology and Endocrinology, The University of Tokyo Hospital, Tokyo, Japan.
Daisuke YamadaDepartment of Hemodialysis and Apheresis, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Masaomi NangakuDepartment of Hemodialysis and Apheresis, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSkin perfusion pressure (SPP) is a noninvasively obtained and useful measurement for assessing peripheral arterial disease (PAD). Decreased SPP in lower extremities is associated with poor survival in maintenance haemodialysis (HD) patients. Nevertheless, the prognostic significance of SPP at HD initiation has not been determined. We investigated the relation between SPP and death or cardiovascular disease (CVD) in incident HD patients.

methodsData were collected retrospectively from patients with SPP measurements taken by dialysis nurses at HD initiation during 2020-2023. Then we assessed the association between the minimum value of SPP in the bilateral dorsal/plantar portions of each patient (SPPmin) and outcomes, consisting of mortality and CVDs within 1 year after HD initiation.

resultsThis study examined 104 incident HD patients with a median age of 74 (79% male). Based on the suggested cut-off value from receiver operating characteristic analysis, patients were divided into two groups: patients with SPPmin ≥ 60 mmHg (higher SPPmin) and those with SPPmin < 60 mmHg (lower SPPmin). Kaplan-Meier analysis indicated the 1-year survival and CVD-free rate as significantly lower in the lower SPPmin group than in the higher SPPmin group (p < .001). Cox proportional hazards analyses showed lower SPPmin as associated with the composite outcome. The relation between lower SPPmin and outcome held true in each subgroup with cardiovascular risk such as older age and history of CVD.

conclusionSPP measured by dialysis nurses at HD initiation is associated with 1-year adverse outcomes in incident HD patients.

Indexed as

Cardiovascular DiseasesLower ExtremityPeripheral Arterial DiseaseRenal DialysisSkinAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsTime FactorsDialysis nurseHaemodialysisPeripheral arterial disease (PAD)Skin perfusion pressure (SPP)

Identifiers

PMID40266539
PMCPMC12441104

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