Evidence map›Paper›PMID 40266537›Full record

ArticleHormones (Athens, Greece)2025

Quality of life in thyroid cancer survivors with and without permanent hypoparathyroidism.

Matthias Büttner, Gerasimos Sykiotis, Akram Al-Ibraheem, Monica Pinto, Ioannis Iakovou, Arild Andre Østhus, Eva Hammerlid, Laura Deborah Locati, Eva Maria Gamper, Juan Ignacio Arraras and 14 more

Abstract read
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Article in Hormones (Athens, Greece), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Matthias BüttnerInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre Mainz, Mainz, Germany. matbuett@uni-mainz.de.ORCID http://orcid.org/0000-0002-7000-8257
Gerasimos SykiotisService of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-9565-4941
Akram Al-IbraheemDepartment of Nuclear Medicine, King Hussein Cancer Center, Amman, Jordan.ORCID http://orcid.org/0000-0002-0978-4716
Monica PintoRehabilitation Medicine Unit, Strategic Health Services Department, Istituto Nazionale Tumori- IRCCS- Fondazione G. Pascale, Naples, Italy.ORCID http://orcid.org/0000-0002-0823-4907
Ioannis IakovouDepartment of Nuclear Medicine, Aristotle University, Thessaloniki, Greece.
Arild Andre ØsthusENT and Head and Neck Department, University Medical Centre Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-0583-4106
Eva HammerlidInstitute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-1813-108X
Laura Deborah LocatiDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.ORCID http://orcid.org/0000-0003-3315-2580
Eva Maria GamperDepartment of Nuclear Medicine and Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0002-1700-4054
Juan Ignacio ArrarasOncology Departments, Complejo Hospitalario de Navarra, Pamplona, Spain.ORCID http://orcid.org/0000-0002-4415-2570
Susan J JordanSchool of Public Health, The University of Queensland, Brisbane, Australia.ORCID http://orcid.org/0000-0002-4566-1414
Naomi KiyotaDepartment of Medical Oncology and Hematology, Cancer Center, Kobe University Hospital, Kobe, Japan.ORCID http://orcid.org/0000-0001-8021-6116
Deborah EngesserInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0001-8377-1553
Katherine TaylorInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0003-0768-5789
Rita CanotilhoInstituto Português do Oncologia do Porto Francisco Gentil, Porto, Portugal.ORCID http://orcid.org/0000-0003-3914-0679
Georgios IoannidisOncology Department, Nicosia General Hospital, State Health Services Organization, Nicosia, Cyprus.ORCID http://orcid.org/0000-0003-2535-7279
Olga HussonDivision of Medical Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands.ORCID http://orcid.org/0000-0002-1387-8686
Ricardo Ribeiro GamaHead and Neck Surgery Department, Barretos Cancer Hospital, Barretos, Brazil.ORCID http://orcid.org/0000-0003-4406-8958
Giuseppe FanettiDivision of Radiotherapy, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, PN, Italy.ORCID http://orcid.org/0000-0002-9677-3176
Laura MossVelindre Cancer Centre, Velindre University NHS Trust, Cardiff, UK.
Johanna InhesternDepartment of Otorhinolaryngology, Oberhavelkliniken, Hennigsdorf, Germany.ORCID http://orcid.org/0000-0003-4613-2810
Guy AndrySurgery Department, Jules Bordet Institute, Brussels, Belgium.ORCID http://orcid.org/0000-0001-7410-6519
Harald RimmeleBundesverband Schilddrüsenkrebs - Ohne Schilddrüse leben e. V., Berlin, Germany.
Susanne SingerInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0001-5784-7964

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHypoparathyroidism (HypoPT) is one of the most common complications of surgical treatment for thyroid cancer and afflicated patients often report symptoms or impairments in quality of life (QoL). We aimed to investigate differences in various QoL domains between thyroid cancer survivors with and without permanent hypoparathyroidism.

methodsThyroid cancer survivors with a minimum of 1.5 years post-diagnosis completed the EORTC core questionnaire (EORTC QLQ-C30) and the EORTC thyroid module (QLQ-THY34). Sociodemographic and clinical information were obtained from the patients themselves and their medical charts. Analysis of covariance was used to compare QoL between survivors with and without hypoparathyroidism (adjusting for age, gender, time since diagnosis, and comorbidity).

resultsOf the 126 participants, 21 (17%) were diagnosed with permanent HypoPT. There was no evidence of differences regarding any QoL domain between survivors due to hypoparathyroidism. The symptoms with the highest burden for both groups were fatigue (hypoPT: 24.9; non-hypoPT: 32.8; p = 0.151) and insomnia (hypoPT: 22.2; non-hypoPT: 30.8; p = 0.213). Thyroid cancer specific impairments were observed for joint pain (hypoPT: 28.6; non-hypoPT: 34.0; p = 0.480), worry about important others (hypoPT: 25.8; non-hypoPT: 27.9; p = 0.765), exhaustion (hypoPT: 23.8; non-hypoPT: 27.9; p = 0.482), and lacking social support (hypoPT: 36.5; no-hypoPT: 23.0; p = 0.070).

conclusionThe present study appears to show that QoL in thyroid cancer survivors may be unrelated to hypoparathyroidism, further suggesting a more complex relationship between these two aspects.

Indexed as

Cancer SurvivorsHypoparathyroidismQuality of LifeThyroid NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedSurveys and QuestionnairesHypoparathyroidismQuality of lifeSurvivorsThyroid cancer

Identifiers

PMID40266537

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.