ArticleBiological trace element research2025
The Relationship Between Magnesium Depletion Score and Kidney Stone Risk in Gout Patients: a Mediation Analysis.
Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Elevated serum cystatin C predicts tophus formation in gout: evidence from a cross-sectional study.Frontiers in endocrinology · 2026Article
- Magnesium Depletion Score as an Indicator of Health Risk and Nutritional Status-A Scoping Review.Nutrients · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
This study investigated the association and mediating mechanisms between magnesium depletion score (MDS) and kidney stones (KDS) in gout patients through a cross-sectional analysis. Logistic regression analysis of 502 gout patients revealed a significant positive association between MDS grade and KDS (OR = 2.14, 95% CI: 1.78-2.58), with the risk remaining elevated in the MDS4 group after adjusting for confounders (OR = 6.25, 95% CI: 2.38-16.44).Causal mediation analysis indicated that MDS fully explained the effect of serum uric acid (SUA) on KDS, suggesting that disrupted magnesium metabolism plays a key role in gout-related kidney injury. Subgroup analysis revealed an increased risk of KDS in obese, hypertensive, and diabetic patients with MDS. MDS should be incorporated into clinical risk assessments for gout, and magnesium supplementation or combined uric acid-lowering therapy should be recommended for high-risk groups to prevent KDS.
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Registered trials
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