ArticleAnnals of nuclear medicine2025
Comparative voxel-based dosimetry with pre-treatment Tc-99m SPECT/CT and post-treatment Y-90 PET/MRI for radioembolization with Y-90 microspheres.
Article in Annals of nuclear medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Multimodal imaging techniques in Yttrium-90 radioembolization for hepatocellular carcinoma: a modality-oriented clinical review.Frontiers in oncology · 2026Review
- Advancing Internal Dosimetry in Personalized Nuclear Medicine: Toward Optimized Radiopharmaceutical Use in Clinical Practice.Pharmaceuticals (Basel, Switzerland) · 2025Article
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Authors and funding
10 authors.
Funding
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Abstract
purposeThe aim of this study was to investigate the differences between voxel-based dosimetry and the mean absorbed doses calculated with pre-treatment Tc-99 m-MAA SPECT/CT and post-treatment Y-90 PET/MR images. We also sought to present a detailed comparison of dose-volume histograms (DVHs) calculated from pre- and post-treatment imaging.
methodsA total of 47 treatments and 41 patients were included in the analysis as six of the treatments were retreatments of the six patients. Multicompartment and voxel-based dosimetry were performed with pre-treatment Tc-99m-MAA SPECT/CT and Y-90 PET/MRI. Correlation coefficients between the two imaging methods for the mean absorbed dose of tumor, whole liver normal tissue, perfused normal tissue, T/N ratio and tumor D10, D50 and D90 values were calculated. Additionally, differences between these values were also evaluated with Bland-Altman plots.
resultsPre-treatment Tc-99m-MAA SPECT/CT accurately predicted the dose values for healthy liver parenchyma calculated with Y-90 PET/MRI but showed lower accuracy in predicting T/N ratio and tumor doses. There were significant variations in tumor-absorbed doses for both glass and resin microspheres. Additionally, D90 values were higher when calculated with SPECT/CT than with PET/MRI, whereas D10 values were higher in PET/MRI compared to SPECT/CT.
conclusionThe findings in our study suggest that Tc-99m-MAA SPECT/CT had higher accuracy in predicting the dose to the healthy liver parenchyma compared to the tumor, maintaining its importance in treatment planning.
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