ArticleJournal of neurology2025
Periaqueductal gray functional connectivity abnormalities associated with acute post-traumatic headache.
Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundThe purpose of this study was to investigate pain network and periaqueductal gray matter (PAG) functional connectivity (FC) in participants with acute post-traumatic headache (PTH) due to mild traumatic brain injury (mTBI) compared to healthy controls (HC).
methodsNinety-eight participants with acute PTH and 85 HC underwent 3 T magnetic resonance imaging. Static FC among regions of the pain matrix and between PAG to the rest of the brain were examined. Correlations between FC and clinical parameters were investigated using linear regression. PTH outcomes (improved or not improved) were determined at 3 months post-enrollment.
resultsStronger FC between the PAG and right somatosensory and left lingual areas, and weaker FC between left thalamus and left caudate were found in the PTH group compared to HC. Whole-brain analysis showed increased PAG FC, primarily with somatosensory, motor, and occipital areas of participants with PTH relative to HC. These differences had associations with headache frequency, state anxiety, and time since mTBI. A PAG FC model for PTH improvement at 3 months had a sensitivity of 82% and a specificity of 100%. Participants with PTH who did not improve at 3 months had stronger baseline FC from the PAG to the right temporal region and the left insula relative to the improved group or to HC.
conclusionPAG FC could serve as an early biomarker identifying participants with acute PTH at risk of developing persistent PTH.
Indexed as
Identifiers
40266360What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.