ArticleThe Plant cell2025
Heat stress triggers enhanced nuclear localization of HYPONASTIC LEAVES 1 to regulate microRNA biogenesis and thermotolerance in plants.
Article in The Plant cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Identification of Candidate Heat-Tolerance Genes in Maize by Integrating Linkage and Transcriptomic Analyses.Plants (Basel, Switzerland) · 2026Article
- Genome-wide analysis of long noncoding RNAs in response to drought stress in the seeds of Brassica napus.BMC genomics · 2026Article
- Heat stress response factor ZmHSF10 positively regulates heat tolerance in maize.BMC plant biology · 2025Article
- Emergence and evolution of canonical microRNAs: A case study in Arabidopsis halleri and A. lyrata.The Plant cell · 2025Article
- When the heat is on, HYL1 steps in: Regulating miRNA biogenesis for plant thermotolerance.The Plant cell · 2025Article
- Cloning and high temperature tolerance analysis of the thermal response related geneFrontiers in plant science · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
Plants have evolved a complex regulatory network to cope with heat stress (HS), which includes microRNAs (miRNAs). However, the roles of the entire miRNA biogenesis machinery in HS responses remain unclear. Here, we show that HS induces the majority of miRNAs primarily through the enhanced nuclear localization of HYPONASTIC LEAVES 1 (HYL1), rather than by upregulating MIR gene transcription in Arabidopsis (Arabidopsis thaliana). Disruption of miRNA biogenesis increases plant susceptibility to HS. We also demonstrate that HYL1 phosphorylation modulates its nuclear localization during HS, which is critical for miRNA induction and thermotolerance. MAP KINASE3 (MPK3) phosphorylates and stabilizes the phosphatase C-TERMINAL DOMAIN PHOSPHATASE-LIKE 1 (CPL1), while CPL1 inhibits MPK3 activity, creating a feedback loop that regulates HYL1 phosphorylation. Disruption of MPK3 function results in increased nuclear HYL1 levels and miRNA production, conferring enhanced HS tolerance to mpk3 mutants. These findings reveal a mechanism by which plants enhance miRNA biogenesis during HS, offering insights into the regulatory networks that govern plant thermotolerance.
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