Evidence map›Paper›PMID 40266232›Full record

ArticleThe ISME journal2025

Synthetic microbial community improves chicken intestinal homeostasis and provokes anti-Salmonella immunity mediated by segmented filamentous bacteria.

Meihong Zhang, Suxin Shi, Yimei Feng, Fengwenhui Zhang, Yuxuan Xiao, Xin Li, Xingliang Pan, Yuqing Feng, Dan Liu, Yuming Guo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The ISME journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Meihong ZhangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Haidian District, Beijing 100193, China.
Suxin ShiState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Haidian District, Beijing 100193, China.
Yimei FengState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Haidian District, Beijing 100193, China.
Fengwenhui ZhangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Haidian District, Beijing 100193, China.
Yuxuan XiaoState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Haidian District, Beijing 100193, China.
Xin LiState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Haidian District, Beijing 100193, China.
Xingliang PanDepartment of Microbiology, Beijing General Station of Animal Husbandry, Chaoyang District, Beijing 100107, China.
Yuqing FengState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Haidian District, Beijing 100193, China.
Dan LiuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Haidian District, Beijing 100193, China.
Yuming GuoState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Haidian District, Beijing 100193, China.
Yongfei HuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Haidian District, Beijing 100193, China.

Funding

National Key Research and Development Program of ChinaNational Key Research and Development Program of China 2022YFA1304201Shandong Provincial Key Research and Development Program of ChinaShandong Provincial Key Research and Development Program of China 2024TZXD026
6 · The paper itself

Abstract

Applying synthetic microbial communities to manipulate the gut microbiota is a promising manner for reshaping the chicken gut microbial community. However, it remains elusive the role of a designed microbial community in chicken physiological metabolism and immune responses. In this study, we constructed a 10-member synthetic microbial community (SynComBac10) that recapitulated the phylogenetic diversity and functional capability of adult chicken intestinal microbiota. We found that early-life SynComBac10 exposure significantly enhanced chicken growth performance and facilitated the maturation of both the intestinal epithelial barrier function and the gut microbiota. Additionally, SynComBac10 promoted the pre-colonization and growth of segmented filamentous bacteria (SFB), which in turn induced Th17 cell-mediated immune responses, thereby conferring resistance to Salmonella infection. Through metagenomic sequencing, we assembled the genomes of two distinct species of SFB from the chicken gut microbiota, which displayed common metabolic deficiencies with SFB of other host origins. In silico analyses indicated that the SynComBac10-stimulated early establishment of SFB in the chicken intestine was likely through SynComBac10-derived metabolite cross-feeding. Our study demonstrated the pivotal role of a designed microbial consortium in promoting chicken gut homeostasis and anti-infection immunity, providing a new avenue for engineering chicken gut microbiota.

Indexed as

BacteriaChickensGastrointestinal MicrobiomeHomeostasisIntestinesSalmonellaSalmonella Infections, AnimalAnimalsPhylogenyPoultry Diseasesintestinal homeostasisSalmonellasegmented filamentous bacteriasynthetic microbial community

Identifiers

PMID40266232
PMCPMC12527353

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.