Evidence map›Paper›PMID 40266206›Full record

ArticleVaccines2025

Protection Against Pneumonia Induced by Vaccination with Fimbriae Subunits from

Lucas Assoni, Isabelle Ciaparin, Monalisa Martins Trentini, Juliana Baboghlian, Gabriel Rodrigo, Brenda Vieira Ferreira, José Aires Pereira, Carlos Martinez, Lucio Ferraz, Raquel Girardello and 4 more

Abstract read
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Materials today. Bio · 2026
    Article
  5. InactivatedVaccines · 2026
    Article
  6. Fimbriae potentiateCurrent research in microbial sciences · 2026
    Review
  7. Article
  8. Article
  9. Antibiotic resistance inFrontiers in microbiology · 2026
    Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lucas AssoniLaboratório de Microbiologia Molecular e Clínica, Universidade São Francisco, Bragança Paulista 12916-900, Brazil.
Isabelle CiaparinLaboratório de Microbiologia Molecular e Clínica, Universidade São Francisco, Bragança Paulista 12916-900, Brazil.
Monalisa Martins TrentiniLaboratório Especial de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo 05508-040, Brazil.
Juliana BaboghlianLaboratório de Microbiologia Molecular e Clínica, Universidade São Francisco, Bragança Paulista 12916-900, Brazil.ORCID 0009-0004-4363-270X
Gabriel RodrigoLaboratório de Microbiologia Molecular e Clínica, Universidade São Francisco, Bragança Paulista 12916-900, Brazil.
Brenda Vieira FerreiraLaboratório de Microbiologia Molecular e Clínica, Universidade São Francisco, Bragança Paulista 12916-900, Brazil.
José Aires PereiraLaboratório de Investigações Médicas, Universidade São Francisco, Bragança Paulista 12916-900, Brazil.
Carlos MartinezLaboratório de Investigações Médicas, Universidade São Francisco, Bragança Paulista 12916-900, Brazil.ORCID 0000-0001-8088-427X
Lucio FerrazLaboratório de Microbiologia Molecular e Clínica, Universidade São Francisco, Bragança Paulista 12916-900, Brazil.ORCID 0000-0002-3818-3215
Raquel GirardelloLaboratório de Microbiologia Molecular e Clínica, Universidade São Francisco, Bragança Paulista 12916-900, Brazil.ORCID 0000-0002-7117-0651
Lucas Miguel CarvalhoLaboratório de Biologia de Sistemas e Ômicas em Ciências da Saúde (LaBSOmiCS), Universidade São Francisco, Bragança Paulista 12916-900, Brazil.ORCID 0000-0002-8766-0452
Anders P HakanssonDivision of Experimental Infection Medicine, Department of Translational Medicine, Lund University, 222 42 Lund, Sweden.ORCID 0000-0002-2834-6009
Thiago Rojas ConversoLaboratório de Microbiologia Molecular e Clínica, Universidade São Francisco, Bragança Paulista 12916-900, Brazil.ORCID 0000-0001-5631-4541
Michelle DarrieuxLaboratório de Microbiologia Molecular e Clínica, Universidade São Francisco, Bragança Paulista 12916-900, Brazil.ORCID 0000-0002-7829-3435

Funding

Coordination for the Improvement of Higher Education Personnel (CAPES) 88887.601281/2021-00São Paulo Research Foundation (FAPESP) 2023/10579-8
6 · The paper itself

Abstract

background

methodsMrkA and FimA were produced as recombinant proteins in

resultsSubcutaneous immunization with recombinant FimA and MrkA induced high IgG1 production; the antibodies efficiently recognized the native proteins at the bacterial surface, promoted C3 deposition and reduced biofilm formation by

conclusionThe results suggest that both type 1 and type 3 fimbriae contribute to protection against

Indexed as

biofilmsfimbriaeK. pneumoniaeprotein vaccines

Identifiers

PMID40266206
PMCPMC11945627

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.