Evidence map›Paper›PMID 40266137›Full record

ArticleVaccines2025

Recombinant Detoxified Holotoxin as a Potent Candidate Vaccine Against Botulism.

Zhixin Meng, Chunlin Cheng, Guoqing Xiong, Jiazhen Cui, Yuzhong Feng, Zhili Chen, Yuanyuan Lu, Xuan Huang, Qi Yang, Qi Xin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhixin MengKey Laboratory of Microbial Diversity Research and Application of Hebei Province, Department of Microbial and Biochemical Pharmaceutics, College of Life Science, Hebei University, 180 Wusi East Road Street, Baoding 071002, China.
Chunlin ChengKey Laboratory of Microbial Diversity Research and Application of Hebei Province, Department of Microbial and Biochemical Pharmaceutics, College of Life Science, Hebei University, 180 Wusi East Road Street, Baoding 071002, China.
Guoqing XiongAcademy of Military Medical Sciences, Beijing 100071, China.
Jiazhen CuiAcademy of Military Medical Sciences, Beijing 100071, China.
Yuzhong FengAcademy of Military Medical Sciences, Beijing 100071, China.
Zhili ChenAcademy of Military Medical Sciences, Beijing 100071, China.
Yuanyuan LuAcademy of Military Medical Sciences, Beijing 100071, China.
Xuan HuangAcademy of Military Medical Sciences, Beijing 100071, China.
Qi YangAcademy of Military Medical Sciences, Beijing 100071, China.
Qi XinKey Laboratory of Microbial Diversity Research and Application of Hebei Province, Department of Microbial and Biochemical Pharmaceutics, College of Life Science, Hebei University, 180 Wusi East Road Street, Baoding 071002, China.
Xin GeKey Laboratory of Microbial Diversity Research and Application of Hebei Province, Department of Microbial and Biochemical Pharmaceutics, College of Life Science, Hebei University, 180 Wusi East Road Street, Baoding 071002, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccination may represent a suitable strategy for preventing botulism. The recombinant expression of toxin functional domains can induce effective immune responses against botulism. This study aims to develop a safe and effective recombinant detoxified full-length BoNTA vaccine. In this study, we engineered and mutated the toxin activity-related sites on the basis of the full-length BoNTA protein and constructed three detoxified full-length toxin mutants. They were recombinant expressed and purified in

Indexed as

botulinum neurotoxinbotulismdetoxified holotoxinimmunogenicitytoxicity

Identifiers

PMID40266137
PMCPMC11946686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.