ArticleVaccines2025
Antibody Persistence of Human Diploid Cell Rabies Vaccine Administrated Using the Four-Versus Five-Dose Essen Intramuscular Regimen in Post-Exposure Prophylaxis: A Prospective Cohort Study Among the Chinese Population.
Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Risk factors for adverse events following rabies vaccination: a multivariate analysis of real-world data.Frontiers in public health · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveEvidence on long-term antibody persistence for the rabies vaccine administered using the four-dose Essen regimen is lacking. This study compared antibody persistence for the human diploid cell rabies vaccine (HDCV) administered using the four- versus five-dose Essen intramuscular regimen in post-exposure prophylaxis (PEP).
methodsThis prospective cohort study enrolled patients vaccinated with the lyophilized HDCV for PEP who were grouped into four-dose and five-dose Essen groups. Rabies virus-neutralizing antibody (RVNA) detection was performed at 1 year or 3 years after initial vaccination.
resultsIn total, 180 and 184 patients were included in the four- and five-dose groups, respectively. The 1-year seroconversion (>0.5 IU/mL) rates were similar in the five-dose and four-dose Essen groups (99.2% vs. 98.3%,
conclusionsThe four- and five-dose Essen regimens effectively produce durable immunogenicity, supporting the feasibility of implementing the four-dose Essen regimen for rabies immunization in China.
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