Evidence map›Paper›PMID 40266065›Full record

ArticleVaccines2025

Computationally Selected Multivalent HIV-1 Subtype C Vaccine Protects Against Heterologous SHIV Challenge.

Dieter Mielke, Marina Tuyishime, Natasha S Kelkar, Yunfei Wang, Robert Parks, Sampa Santra, Wes Rountree, LaTonya D Williams, Tiffany Peters, Nathan Eisel and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Dieter MielkeDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.ORCID 0000-0003-2182-0510
Marina TuyishimeDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.ORCID 0000-0002-6940-3639
Natasha S KelkarDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, NH 03756, USA.ORCID 0009-0007-2942-7488
Yunfei WangDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.ORCID 0000-0002-3205-6338
Robert ParksDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.ORCID 0000-0002-6259-7610
Sampa SantraBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-8796-1714
Wes RountreeDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.ORCID 0000-0001-5183-6949
LaTonya D WilliamsDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.ORCID 0000-0001-8064-8533
Tiffany PetersDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.
Nathan EiselDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.ORCID 0000-0003-4217-2495
Sheetal SawantDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.ORCID 0000-0002-1109-7907
Lu ZhangDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.
Derrick GoodmanDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.
Shalini JhaDepartment of Surgery, Duke University, Durham, NC 27710, USA.
Adam ZalaquettDepartment of Surgery, Duke University, Durham, NC 27710, USA.
Pratamesh RamasubramanianDepartment of Surgery, Duke University, Durham, NC 27710, USA.
Sherry Stanfield-OakleyDepartment of Surgery, Duke University, Durham, NC 27710, USA.
Gary MatyasU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0002-2074-2373
Zoltan BeckU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Mangala RaoU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0001-9553-4969
Julie AkeU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Thomas N DennyDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.
David C MontefioriDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.
Margaret E AckermanDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, NH 03756, USA.ORCID 0000-0002-4253-3476
Lawrence CoreyVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98104, USA.
Georgia D TomarasDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.
Bette T KorberT-6: Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.ORCID 0000-0002-2026-5757
Barton F HaynesDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.
Xiaoying ShenDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.ORCID 0000-0002-8387-3952
Guido FerrariDuke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.ORCID 0000-0001-7747-3349

Funding

LOC: HIV Vaccine Trials NetworkUM1AI068614 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Dan H. Barouch, Lawrence Corey · 2011 to 2026
$1175.6M
Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
NIAID NIH HHS P30 AI064518NIAID NIH HHS UM1 AI068614
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

correlate of protectionHIV-1subtype Csystems serologyvariable loops 1 and 2

Identifiers

PMID40266065
PMCPMC11945704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.