Evidence map›Paper›PMID 40266001›Full record

ArticleJournal of magnetic resonance imaging : JMRI2025

Design and Implementation of a Multi-Center Trial of

Bastiaan Driehuys, Shuo Zhang, Aryil Bechtel, Andrew D Hahn, Guilhem Collier, Peter J Niedbalski, Yuh-Chin Huang, Zackary I Cleveland, Matthew M Willmering, John P Mugler and 18 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Bastiaan DriehuysDepartment of Radiology, Duke University Medical Center, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-1236-4210
Shuo ZhangDepartment of Radiology, Duke University Medical Center, Durham, North Carolina, USA.
Aryil BechtelDepartment of Radiology, Duke University Medical Center, Durham, North Carolina, USA.
Andrew D HahnDepartment of Radiology, University of Iowa, Iowa City, Iowa, USA.ORCID https://orcid.org/0000-0002-0246-2108
Guilhem CollierPOLARIS, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Peter J NiedbalskiDepartment of Pulmonary, Critical Care, and Sleep of Kansas Medical Center, Kansas City, Kansas, USA.
Yuh-Chin HuangDepartment of Medicine, Duke University, Durham, North Carolina, USA.
Zackary I ClevelandCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Matthew M WillmeringCenter for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
John P MuglerDepartment of Radiology & Medical Imaging, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Jaime MataDepartment of Radiology & Medical Imaging, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Yun Michael ShimDepartment of Radiology & Medical Imaging, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Mario CastroDepartment of Pulmonary, Critical Care, and Sleep of Kansas Medical Center, Kansas City, Kansas, USA.
Sarah SvenningsenDepartment of Medicine, McMaster University, Hamilton, Canada.ORCID https://orcid.org/0000-0002-6225-1863
Yonni FriedlanderDepartment of Medicine, McMaster University, Hamilton, Canada.
Terence HoDepartment of Medicine, McMaster University, Hamilton, Canada.
Sean FainDepartment of Radiology, University of Iowa, Iowa City, Iowa, USA.ORCID https://orcid.org/0000-0001-5461-0646
Eric A HoffmanDepartment of Radiology, University of Iowa, Iowa City, Iowa, USA.
Jim M WildPOLARIS, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.ORCID https://orcid.org/0000-0002-7246-8660
Robert P ThomenDepartment of Radiology, University of Missouri, Columbia, Missouri, USA.
Talissa AltesDepartment of Radiology, University of Missouri, Columbia, Missouri, USA.
Ummul Afia ShammiRichard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, Illinois, USA.
Will HarrisGenentech Inc., OMNI Early Clinical Development, South San Francisco, California, USA.
Yixuan ZouGenentech Inc., OMNI Early Clinical Development, South San Francisco, California, USA.
Alexandre Fernandez CoimbraGenentech Inc., OMNI Early Clinical Development, South San Francisco, California, USA.
Paula BelloniGenentech Inc., OMNI Early Clinical Development, South San Francisco, California, USA.
Laura C BellGenentech Inc., OMNI Early Clinical Development, South San Francisco, California, USA.ORCID https://orcid.org/0000-0001-8164-8324
David MummyDepartment of Radiology, Duke University Medical Center, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0001-7885-109X

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5M
Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRIR01HL105643 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2011 to 2026
$6.7M
Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary FibrosisR01HL126771 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2015 to 2026
$6.6M
Hyperpolarized 129Xe MRI to identify structural determinants of low lung function and respiratory symptoms in young adults from the Lung Health CohortR01HL168446 · NHLBI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Peter James Niedbalski · 2023 to 2026
$3.2M
Proton and hyperpolarized xenon pulmonary MRI at 0.55TU01HL178354 · NHLBI · UNIVERSITY OF VIRGINIA · PI Adrienne Campbell, CRAIG H MEYER · 2025 to 2026
$1.2M
Hyperpolarized Xe-129 MRI for Functional Lung PhenotypingS10OD026960 · OD · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2019 to 2019
$600k
GenentechNHLBI NIH HHS R01 HL105643NHLBI NIH HHS R01 HL126771NHLBI NIH HHS R01 HL168446NHLBI NIH HHS U01 HL178354NIEHS NIH HHS P30 ES005605NIH HHS 1S10OD026960NIH HHS R01HL105643NIH HHS R01HL126771NIH HHS R01HL168446NIH HHS S10 OD026960
6 · The paper itself

Abstract

MR imaging holds the potential to enhance drug development efficiency by de-risking early phase studies and increasing confidence in results. It can improve patient selection, increase repeatability, and provide greater sensitivity to change, thereby enabling smaller, faster clinical trials. For trials in the pulmonary space, hyperpolarized

Indexed as

Magnetic Resonance ImagingPulmonary Disease, Chronic ObstructiveXenon IsotopesClinical Trials as TopicDisease ProgressionHumansImaging, Three-DimensionalLongitudinal StudiesLungMagnetic Resonance SpectroscopyMaleMulticenter Studies as TopicReproducibility of ResultsXenon-129Xenon Isotopes129Xe MRIchronic obstructive pulmonary diseaseguidelineslongitudinal

Identifiers

PMID40266001
PMCPMC12353566

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.