ArticleMovement disorders clinical practice2025
Cognitive Outcomes Following Second-Sided Focused Ultrasound Thalamotomy for Tremor.
Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Staged Bilateral Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor: Prospective Single-Centre Cohort and Systematic Review With Meta-Analysis.European journal of neurology · 2026Pooled it
- Staged Bilateral Magnetic Resonance-Guided Focused Ultrasound for Treating Essential Tremor: Systematic Review and Meta-Analysis.Movement disorders clinical practice · 2026Review
- Tremor Recurrence in MR-Guided Focused Ultrasound Thalamotomy for Essential Tremor: DBS vs. Re-lesion.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
backgroundHistorically, staged bilateral thalamotomy has been associated with cognitive decline.
objectiveTo examine cognitive outcomes of second-sided focused ultrasound (FUS) thalamotomy in individuals with medication-refractory essential tremor (ET) who previously underwent unilateral FUS thalamotomy.
methodsTwenty-one individuals with medication-refractory ET completed cognitive testing before undergoing second-sided FUS thalamotomy and 4 months post-FUS. Cognitive changes were analyzed at the group and individual levels.
resultsAt the group level, no significant declines were observed on any of the test scores. At the individual level, most cognitive test scores remained stable (95% of scores), with declines (2% of scores) and improvements (3% of scores) occurring infrequently. Specifically, declines were observed on only four of the 19 cognitive test scores. No more than two participants declined on any single test score and no participant declined on more than two cognitive test scores.
conclusionsSecond-sided FUS thalamotomy is associated with minimal risk of cognitive decline.
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Registered trials
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