Evidence map›Paper›PMID 40265947›Full record

ArticleAntimicrobial agents and chemotherapy2025

The KasA inhibitor JSF-3285 improves the sterilizing activity of bedaquiline-pretomanid-containing regimens in a mouse model of tuberculosis.

Heena Soni, Sandeep Tyagi, Kishor Mane, Anil M Shelke, Pradeep Kumar, Firat Kaya, David Alland, Matthew Zimmerman, Joel S Freundlich, Eric L Nuermberger

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Heena Soni *Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Sandeep Tyagi *Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Kishor ManeDepartment of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA.
Anil M ShelkeDepartment of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA.
Pradeep KumarDivision of Infectious Disease, Department of Medicine and the Ruy V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA.
Firat KayaCenter for Discovery & Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
David AllandDivision of Infectious Disease, Department of Medicine and the Ruy V. Lourenco Center for the Study of Emerging and Re-emerging Pathogens, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA.ORCID 0000-0001-5196-1571
Matthew ZimmermanCenter for Discovery & Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Joel S FreundlichDepartment of Pharmacology, Physiology, and Neuroscience, Rutgers University-New Jersey Medical School, Newark, New Jersey, USA.ORCID 0000-0002-3411-3455
Eric L NuermbergerCenter for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0003-1440-9889

Funding

A Preclinical Program for Targeting Mycobacterium tuberculosis KasAR01AI153145 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI FREUNDLICH, JOEL STEPHEN · 2021 to 2024
$3.2M
HHS | NIH | All of Us Research Program (All of Us NIH) R01 AI-153145NIAID NIH HHS R01 AI153145
6 · The paper itself

Abstract

JSF-3285 is a promising preclinical candidate for tuberculosis that potently targets the

Indexed as

Antitubercular AgentsDiarylquinolinesMycobacterium tuberculosisNitroimidazolesTuberculosisAnimalsDisease Models, AnimalDrug Therapy, CombinationFemaleMiceMice, Inbred BALB CMicrobial Sensitivity TestsAntitubercular AgentsbedaquilineDiarylquinolinesNitroimidazolespretomanidantitubercularJSF-3285KasAmouse relapse modelMycobacterium tuberculosis

Identifiers

PMID40265947
PMCPMC12135538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.