Evidence map›Paper›PMID 40265937›Full record

ArticleJournal of virology2025

LDHA-lactate axis modulates mitophagy inhibiting CSFV replication.

Sen Zeng, Zipeng Luo, Wenhui Zhu, Zhanhui Zhang, Ruibo Zhao, Shuaiqi Zhu, Qi Qiu, Nan Cao, Xinliang Fu, Wenjun Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sen Zeng *College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.ORCID 0009-0009-8249-1985
Zipeng Luo *College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Wenhui ZhuCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Zhanhui ZhangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Ruibo ZhaoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Shuaiqi ZhuCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Qi QiuCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Nan CaoCollege of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Xinliang FuCollege of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Wenjun LiuCollege of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Shuangqi FanCollege of Veterinary Medicine, South China Agricultural University, Guangzhou, China.ORCID 0009-0005-9975-2978
Cheng FuCollege of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.ORCID 0009-0003-6111-6541

Funding

Natural Science Foundation of Guangdong Province, China No. 2024A1515010943Quality and Efffciency Improvement Project of South China Agricultural University No. C18Science and Technology Projects in Guangzhou No. 2023A04J0743Speciffc University Discipline Construction Project No. 2023B10564003
6 · The paper itself

Abstract

Lactate dehydrogenase A (LDHA) plays a crucial role in regulating lactate synthesis in various biological processes. Lactate, a byproduct of glycometabolism, has been recognized as a unique molecule with implications in both metabolism and immunity. Classical swine fever (CSF), caused by the classical swine fever virus (CSFV), is a highly contagious and severe infectious disease that primarily affects pigs. Prior research has shown that CSFV infection disrupts the normal glycolytic process, leading to an accumulation of lactate within the host. Nevertheless, it remains unclear whether there is mutual regulation between the CSFV and LDHA-lactate axis. Here, we have found that CSFV infection increases LDHA expression IMPORTANCE: This research unveils how CSFV interacts with cellular metabolism through LDHA. By revealing LDHA's dual role and how lactate influences cellular processes during CSFV infection, this study uncovers new pathways for viral replication. These findings not only deepen our understanding of viral-host interactions but also open doors for innovative antiviral strategies centered around manipulating cellular metabolism.

Indexed as

Classical Swine FeverClassical Swine Fever VirusLactate Dehydrogenase 5Lactic AcidL-Lactate DehydrogenaseMitophagyVirus ReplicationAnimalsHumansMitochondriaSwineLactate Dehydrogenase 5Lactic AcidL-Lactate DehydrogenaseCSFVJAK-STATlactateLDHAmitophagy

Identifiers

PMID40265937
PMCPMC12090782

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.