Evidence map›Paper›PMID 40265899›Full record

ArticlemSphere2025

A droplet digital PCR assay to measure pilin antigenic variation frequency in

Sarah J Quillin, Di Luo, Aoife Gavagan, Arthur Prindle, H Steven Seifert

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Restriction-modification systems are required forProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Restriction-modification systems are required forbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sarah J QuillinDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0003-2164-3198
Di LuoDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Aoife GavaganDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Arthur PrindleDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0009-0004-2804-3077
H Steven SeifertDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0001-8651-0375

Funding

Targeting the functions of the gonococcal Type lV pilusR01AI146073 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Hank S. SEIFERT · 2020 to 2026
$3.3M
Emergent metabolic coordination and cell-to-cell signaling in bacterial biofilms-ADMIN SUPP for EquipmentR35GM147170 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Arthur Prindle · 2022 to 2026
$2.1M
Army Research Office W911NF-19-1-0136David and Lucile Packard Foundation 2018-68055National Institute of Allergy and Infectious Diseases R37 AI03349, R01 AI146073National Science Foundation NSF 2239567NIAID NIH HHS R01 AI146073NIGMS NIH HHS R35 GM147170
6 · The paper itself

Abstract

The strict human pathogen IMPORTANCE: Gonorrhea is a sexually transmitted infectious disease of the human genital and nasopharyngeal mucosa caused by the host-restricted bacterium

Indexed as

Antigenic VariationAntigens, BacterialFimbriae ProteinsNeisseria gonorrhoeaePolymerase Chain ReactionGonorrheaHumansAntigens, BacterialFimbriae ProteinspilE protein, Neisseria gonorrhoeaeantigenic variationdigital PCRgene conversionNeisseria gonorrhoeaepilus

Identifiers

PMID40265899
PMCPMC12108084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.