Evidence map›Paper›PMID 40265896›Full record

ArticlemBio2025

Khumoekae Richard, Zhe Yuan, Hsin-Yao Tang, Aaron R Goldman, Riza Kuthu, Boingotlo Raphane, Emery T Register, Paridhima Sharma, Brian N Ross, Jessicamarie Morris and 11 more

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Traditional Medicine Extracts ofInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Khumoekae RichardThe Wistar Institute, Philadelphia, Pennsylvania, USA.
Zhe YuanThe Wistar Institute, Philadelphia, Pennsylvania, USA.
Hsin-Yao TangThe Wistar Institute, Philadelphia, Pennsylvania, USA.
Aaron R GoldmanThe Wistar Institute, Philadelphia, Pennsylvania, USA.
Riza KuthuThe Wistar Institute, Philadelphia, Pennsylvania, USA.
Boingotlo RaphaneUniversity of Botswana, Gaborone, Botswana.
Emery T RegisterThe Wistar Institute, Philadelphia, Pennsylvania, USA.
Paridhima SharmaThe Wistar Institute, Philadelphia, Pennsylvania, USA.
Brian N RossThe Wistar Institute, Philadelphia, Pennsylvania, USA.
Jessicamarie MorrisThe Wistar Institute, Philadelphia, Pennsylvania, USA.
David E WilliamsDepartments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
Carol CheneyMerck and Co Inc, Rahway, New Jersey, USA.
Guoxin WuMerck and Co Inc, Rahway, New Jersey, USA.
Karam MounzerJonathan Lax Immune Disorders Treatment Center, Philadelphia Field Initiating Group for HIV-1 Trials, Philadelphia, Pennsylvania, USA.
Gregory M LairdAccelevirDx, Baltimore, Maryland, USA.
Paul ZuckMerck and Co Inc, Rahway, New Jersey, USA.
Raymond J AndersenDepartments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
Sundana SimonambangoKwame (Legwame) Traditional Association, Mmadinare, Botswana.
Kerstin Andrae-MarobelaUniversity of Botswana, Gaborone, Botswana.
Ian TietjenThe Wistar Institute, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-8991-6490
Luis J MontanerThe Wistar Institute, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-5799-6759

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ronald G Collman · 1999 to 2026
$78.6M
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Aaron Robert Goldman · 1985 to 2026
$75.9M
BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination ImmunotherapyUM1AI164570 · NIAID · WISTAR INSTITUTE · PI Luis J Montaner, James L. Riley · 2021 to 2026
$34.7M
Centralized Resource to Accurately Quantify Latent and Expressed HIV ReservoirsU24AI143502 · NIAID · ACCELEVIR DIAGNOSTICS, LLC · PI LAIRD, GREGORY MICHAEL, MARTIN, ALBINE · 2020 to 2024
$4.9M
Advancing Cancer Research through Comprehensive Proteomics and Metabolomics AnalysesR50CA221838 · NCI · WISTAR INSTITUTE · PI Hsin-Yao Tang · 2017 to 2026
$2.1M
Centralized Resource to Accurately Quantify Latent and Expressed HIVReservoirsR24AI143502 · NIAID · ACCELEVIR DIAGNOSTICS, LLC · PI Gregory Michael Laird, Albine Martin · 2025 to 2026
$2.1M
Purchase of a Q Exactive HF mass spectrometer system for metabolomicsS10OD023586 · OD · WISTAR INSTITUTE · PI SPEICHER, DAVID W. · 2017 to 2017
$600k
CIHR PJT-153057Herbert Kean, M.D., Family Professorship n/aNCI NIH HHS P30 CA010815NCI NIH HHS R50 CA221838New Frontiers in Research Fund - Explorations NFRFE-2018-01386NIAID NIH HHS P30 AI045008NIAID NIH HHS R24 AI143502NIAID NIH HHS U24 AI143502NIAID NIH HHS UM1 AI164570NIH Cancer Center Support Grant CA010815NIH HHS S10 OD023586Penn Center for AIDS Research Grant P30 AI 045008Queen Elizabeth II Diamond Jubilee Scholarship n/aRobert I Jacobs Fund of The Philadelphia Foundation n/aSub-Saharan African Network for TB/HIV Research Excellence DEL-15-006Wellcome TrustW. W. Smith Charitable Trust A2301
6 · The paper itself

Abstract

New HIV latency-reversing agents (LRAs) are needed that can reactivate and/or eliminate HIV reservoirs. "Mukungulu," prepared from the plant

Indexed as

Anti-HIV AgentsCrotonHIV-1HIV InfectionsPlant ExtractsPlants, MedicinalProtein Kinase CVirus LatencyAnimalsBotswanaCD4-Positive T-LymphocytesFemaleHumansLeukocytes, MononuclearMicePhorbol EstersAnti-HIV AgentsPhorbol EstersPlant ExtractsProtein Kinase Cex vivoHIVhumanized micelatency reversalnatural productstraditional medicines

Identifiers

PMID40265896
PMCPMC12077168

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.