Evidence map›Paper›PMID 40265842›Full record

ReviewJournal of virology2025

Advancing curation of viral life cycles, host interactions, and therapeutics in Reactome.

Lisa Matthews, Justin Cook, Ralf Stephan, Marija Milacic, Karen Rothfels, Veronica Shamovsky, Bijay Jassal, Robin Haw, Cristoffer Sevilla, Chuqiao Gong and 13 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Reactome Knowledgebase 2026.Nucleic acids research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Lisa Matthews *Department of Biochemistry and Molecular Pharmacology, NYU Langone Health Center, New York, New York, USA.
Justin CookDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Ralf StephanOntario Institute for Cancer Research, Toronto, Ontario, Canada.ORCID 0000-0002-4650-631X
Marija Milacic *Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Karen Rothfels *Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Veronica ShamovskyDepartment of Biochemistry and Molecular Pharmacology, NYU Langone Health Center, New York, New York, USA.
Bijay JassalOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Robin HawOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Cristoffer SevillaEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
Chuqiao GongEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
Eliot RagueneauOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Bruce MayOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Adam WrightOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Joel WeiserOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Deidre BeaversMedical Informatics and Clinical Epidemiology, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Krishna TiwariEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
Andrea Senff-RibeiroOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Thawfeek VarusaiEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
Henning HermjakobEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom.
Peter D'Eustachio *Department of Biochemistry and Molecular Pharmacology, NYU Langone Health Center, New York, New York, USA.
Guanming WuMedical Informatics and Clinical Epidemiology, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Lincoln SteinOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Marc E GillespieOntario Institute for Cancer Research, Toronto, Ontario, Canada.ORCID 0000-0002-5766-1702

Funding

Reactome: An Open Knowledgebase of Human Pathways.U24HG012198 · NHGRI · ONTARIO INSTITUTE FOR CANCER RESEARCH · PI Marc E Gillespie, LINCOLN D. STEIN · 2022 to 2026
$7.0M
NHGRI NIH HHS U24 HG012198
6 · The paper itself

Abstract

Reactome (reactome.org) is a manually curated, peer-reviewed, open-source, open-access pathway knowledgebase of essential human cellular functions. Reactome includes viral life cycles that capture a broad range of virus-induced human pathology. Here, we describe a workflow using collaborative curation strategies, orthoinference procedures, and literature triage to rapidly create reliable molecular models of emergent viruses. The resulting pathway data set rigorously details viral infection pathways, interactions with normal human biological processes, and potential therapeutic compounds.

Indexed as

Data CurationHost Microbial InteractionsHost-Pathogen InteractionsVirus DiseasesVirusesVirus Physiological PhenomenaDatabases, FactualHumanscommunity collaborationCOVID-19molecular interactionsorthoinferencepathwayReactomeSARS-CoV-2therapeutic compoundsviral lifecycle

Identifiers

PMID40265842
PMCPMC12090728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.