ReviewPlants (Basel, Switzerland)2025
Saponins, the Unexplored Secondary Metabolites in Plant Defense: Opportunities in Integrated Pest Management.
Review in Plants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Overview of molecular mechanisms underlying stress responses; signaling pathways and secondary metabolite synthesis in plants.Plant molecular biology · 2026Review
- Complete biosynthesis of the clinical agent escin Ia.Nature communications · 2026Article
- Widely targeted metabolomics reveals organ-specific metabolite accumulation and functional differentiation of leaves, pulp and seeds in wild jujube (Ziziphus jujuba var. spinosa).BMC plant biology · 2026Article
- Traditional Uses, Phytochemicals, Biological Activities, and Biotechnological Applications ofMolecules (Basel, Switzerland) · 2026Review
- Integrative transcriptomics and defense-related gene family analysis reveals key genes for maize resistance to fall armyworm.BMC plant biology · 2026Article
- Stress-Induced Plant Specialized Metabolism: Signaling, Multi-Omics Integration, and Plant-Derived Antimicrobial Metabolites to Combat Antimicrobial Resistance.Plants (Basel, Switzerland) · 2026Review
- Article
- Plant resistance: scientific basis and latest research progress.Frontiers in plant science · 2026Review
- Phytochemistry and insecticidal activity of six local plant extracts against Sitotroga Cerealella (Oliv.) (Lepidoptera: Gelechiidae) in stored wheat.BMC plant biology · 2025Article
- A Review of Bryophytes: Enzymatic and Non-Enzymatic Antioxidants as a Key for Their Pharmacological Potential and Green-Biotechnological Application.Antioxidants (Basel, Switzerland) · 2025Review
- Transcriptomic analysis of a compatible tobacco-herbivore interaction and the role of jasmonoyl-L-isoleucine hydrolase 1 in response to growth/defense trade-off.BMC plant biology · 2025Article
- In Vitro Evaluation of the Antifungal Activity ofPlants (Basel, Switzerland) · 2025Article
- Review
- Secondary Metabolites in Plants.Plants (Basel, Switzerland) · 2025Article
- Genome-wide identification and functional validation of sterol C-22 desaturases and C-24 methyltransferases inFrontiers in plant science · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants are exposed to a diverse range of biotic stressors, including fungi, bacteria, nematodes, insects and viruses. To combat these enemies, plants have developed an arsenal of defense mechanisms over time, among which secondary metabolites are the most effective. Moreover, to overcome the negative impact of chemical pesticides, the plant's secondary metabolites can be harnessed to develop novel disease management strategies. Alkaloids, flavonoids, terpenes and essential oils are major pathogen/pest-responsive secondary metabolite classes in plants. Among these, saponins have shown significant potential in suppressing a wide range of plant pathogens. However, they are yet to be explored thoroughly compared to other secondary metabolites in plant defense, and therefore, a low number of disease control agents exist in agri-markets based on saponins. Thus, this review aims to rectify this bias by identifying and acknowledging the significance of saponins as being on par with other classes of secondary metabolites in plant defense systems. It also provides the first holistic review on the role of saponins with known mechanisms against all of the major plant pathogens/pests. Furthermore, this review discusses the potential of saponin-rich crops in providing eco-friendly pest/pathogen management products for integrated pest management (IPM) and prospectives on the potential of saponin derivatives in developing novel biocides for sustainable agriculture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.