ArticleJournal of the American Heart Association2025
Are We Getting Better?: Ongoing Challenges of Atrioventricular Valve Repair in Children With Single Ventricle Physiology.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to assess impact of atrioventricular valve (AVV) regurgitation onset, timing of AVV repair (AVVr), ventricular morphology, and era effect on AVVr outcomes in a single ventricle population.
methodsA retrospective review of 155 patients with single ventricle physiology who underwent AVVr between 1998 and 2022 was conducted. Transplant-free survival, discharge alive, and AVV reoperation were assessed using the Kaplan-Meier survival method, stratified by the timing of AVVr (Group1 [G1], prebidirectional cavopulmonary shunt, N=33; G2, at or post-shunt, N=93; G3, at or post-Fontan, N=29). Cox proportional hazard models were used to assess the association of the timing of AVVr with death or transplant.
resultsTransplant-free survival at 10 years was lowest in G1 (G1, 16% [95% CI, 4%-35%]; G2, 65% [95% CI, 53%-74%]; G3, 85% [95% CI, 65%-94%],
conclusionsPatients with single ventricles who required AVVr, particularly before bidirectional cavopulmonary shunt, have poorer transplant-free survival with no meaningful improvement over the past 2 decades. Small weight and morphologic right ventricle were strongly associated with increased mortality. Alternative treatment strategies should be considered for this high-risk subgroup.
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