ArticleJournal of the American Heart Association2025
Does Age Impact Safety and Efficacy During Pulse-Field Ablation for Atrial Fibrillation?
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05617456 (Advanced TecHnologies For SuccEssful AblatioN of AF in Clinical Practice), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Advanced TecHnologies For SuccEssful AblatioN of AF in Clinical Practice: ATHENA Study
Who cites it
7 citing papers in PubMed.
- Procedural Management of Atrial Fibrillation in Older Patients.Reviews in cardiovascular medicine · 2026Review
- Clinical outcomes after catheter ablation for atrial fibrillation in elderly patients: a meta-analysis with time-to-event data reconstruction.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Review
- De Novo Pulmonary Vein Isolation by Means of Pulsed Field Versus Conventional Thermal Ablation of Paroxysmal Atrial Fibrillation in Women: Safety, Efficiency, and Efficacy.Journal of the American Heart Association · 2026Observational
- Safety and Efficacy of Pulsed Field Ablation for Atrial Fibrillation in Elderly Patients.Journal of arrhythmia · 2026Article
- Cardiac biomarker temporal dynamics after radiofrequency and pulsed field catheter ablation of atrial fibrillation.Heart rhythm O2 · 2025Article
- Hemolysis-related acute kidney injury after pulsed field ablation: An emerging concern in patients with hematologic disorders.HeartRhythm case reports · 2025Article
- Safety and feasibility of pulsed field ablation with a pentaspline catheter in patients with cardiac implantable electronic devices: a multicentre experience.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
Corrections and comments
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Authors and funding
27 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is no evidence evaluating efficiency, effectiveness, and safety outcomes in older patients in the context of pulsed-field ablation technology for the ablation of atrial fibrillation. We aimed to compare safety, efficacy, and acute and long-term outcomes of pulsed-field ablation in older patients (≥75 years) with younger ones.
methodsWe enrolled consecutive patients who had undergone atrial fibrillation ablation with the pulsed-field ablation FARAPULSE system (Boston Scientific) at 15 centers. Patients were stratified by age (<65, 65-74, and ≥75 years) and efficacy and safety profiles of these groups were compared.
resultsA total of 1082 patients were included: 108 (10%) were ≥75 years old, 374 (34.6%) were 65-74 years old and 600 (55.4%) were <65 years old. Older patients displayed a more pronounced risk profile compared with their younger counterparts, characterized by a significant higher burden of comorbidities. No differences in terms of procedural metrics were found. Pulmonary vein isolation was achieved in all patients. An overall low rate of procedural-related complications was reported (3.0%) without difference between young and older patients (
conclusionsDrawing from these findings, using the FARAPULSE system for atrial fibrillation ablation in older patients demonstrated swift, safe, and effective acute outcomes, mirroring a comparable pattern observed in younger patients and recurrence rates in line with the literature in older patients. REGISTRATION: URL: clinicaltrials.gov; Unique Identifier: NCT05617456.
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