Evidence map›Paper›PMID 40265582›Full record

Trial reportJournal of the American Heart Association2025

History of Cancer and Atrial Cardiopathy: A Secondary Analysis of the ARCADIA Clinical Trial.

Babak B Navi, Mitchell S V Elkind, Cenai Zhang, David L Tirschwell, Richard A Kronmal, Jordan Elm, Joseph P Broderick, David J Gladstone, Morin Beyeler, Hooman Kamel and 1 more

Registry-linked trialAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03192215 (AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03192215 phase3terminatednot on this map

AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke

TypeinterventionalSponsorColumbia UniversityRan2018 to 2023Enrolled1,015ConditionsStrokeArmsApixaban, Aspirin
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Babak B NaviClinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology Weill Cornell Medicine New York NY USA.ORCID 0000-0001-8424-6128
Mitchell S V ElkindDepartment of Neurology, Vagelos College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health Columbia University New York NY USA.ORCID 0000-0003-2562-1156
Cenai ZhangClinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology Weill Cornell Medicine New York NY USA.ORCID 0000-0001-8137-1644
David L TirschwellDepartment of Neurology University of Washington Seattle WA USA.ORCID 0000-0002-8059-2901
Richard A KronmalDepartment of Biostatistics University of Washington Seattle WA USA.ORCID 0000-0002-9897-7076
Jordan ElmDepartment of Biostatistics Medical University of South Carolina Charleston SC USA.ORCID 0000-0002-4893-8474
Joseph P BroderickDepartment of Neurology and Rehabilitation Medicine University of Cincinnati College of Medicine Cincinnati OH USA.ORCID 0000-0002-7323-7709
David J GladstoneSunnybrook Research Institute, Hurvitz Brain Sciences Program, Sunnybrook Health Sciences Centre, and Division of Neurology, Department of Medicine University of Toronto Toronto ON Canada.
Morin BeyelerClinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology Weill Cornell Medicine New York NY USA.ORCID 0000-0001-5911-7957
Hooman KamelClinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology Weill Cornell Medicine New York NY USA.ORCID 0000-0002-5745-0307
W T LongstrethDepartment of Neurology University of Washington Seattle WA USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Workshop to Identify Collaborative Project(s) for the NIH StrokeNet and the Japan NEtwork for Clinical Stroke Trials (NECST)U01NS087748 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Catherine R. Dillon, Jordan J. Elm · 2014 to 2026
$14.1M
NCI NIH HHS P30 CA008748NINDS NIH HHS U01 NS087748
6 · The paper itself

Abstract

backgroundApproximately 50% of strokes in patients with cancer are classified as cryptogenic after standard evaluation. Atrial cardiopathy could explain some cancer-related cryptogenic strokes. However, the relationship between cancer and atrial cardiopathy is uncertain. METHODS AND

resultsWe conducted a post hoc cross-sectional analysis of baseline data collected from participants enrolled in ARCADIA (Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke), a clinical trial conducted from 2018 to 2023 at 185 sites. The analytical cohort presented herein included patients age ≥45 years with cryptogenic ischemic stroke within the past 180 days, of whom a subset had atrial cardiopathy and were randomized into the trial. Atrial fibrillation before enrollment was exclusionary. Linear regression models examined the associations between history of cancer and the atrial cardiopathy biomarkers analyzed in ARCADIA: serum NT-proBNP (N-terminal pro-B-type natriuretic peptide), P-wave terminal force in ECG lead V

conclusionsIn a multicenter, prospective, cryptogenic stroke cohort, history of cancer was not associated with selected biomarkers for atrial cardiopathy. REGISTRATION: URL: https://www.ClinicalTrials.gov; Unique Identifier: NCT03192215.

Indexed as

Heart AtriaHeart DiseasesIschemic StrokeNeoplasmsAgedBiomarkersCross-Sectional StudiesFemaleFibrinolytic AgentsHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsRisk AssessmentRisk FactorsBiomarkersFibrinolytic AgentsNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)atrial cardiopathycancercryptogenic strokerisk factor

Identifiers

PMID40265582
PMCPMC12184225

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.