ArticleJournal of cosmetic dermatology2025
Clinical Studies on the Application of Concentrated Growth Factors for Enhancing the Recovery From Flap Ischemia-Reperfusion Injuries.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Remote Ischemic Preconditioning Enhances Skin Flap Survival via ZNF667/SDF1-Mediated Endothelial Progenitor Cells Functions for Angiogenesis.Tissue engineering and regenerative medicine · 2026Article
- Regenerative Approach for Improving Flap Survival: Perspective of Angiogenesis.Biomimetics (Basel, Switzerland) · 2026Review
- Evaluation of palatal donor site wound healing with concentrated growth factor after gingival graft procedures.BMC oral health · 2025Article
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Authors and funding
2 authors.
Funding
Abstract
objectiveTo evaluate the therapeutic potential of locally injecting concentrated growth factor (CGF) into flaps for treating flap ischemia-reperfusion injury (FIRI) following reconstructive surgery.
methodsNineteen patients with FIRI were enrolled in this study. After clinical identification of ischemia-reperfusion (IR) injury, CGF was prepared from each patient's autologous blood and locally injected into the affected flap tissue. Flap viability was assessed using clinical indicators such as color, texture, and capillary refill. Patients were followed for 6 months postoperatively to assess long-term outcomes.
resultsSeven days after CGF injection, 18 of 19 patients demonstrated complete flap survival. In one case, total necrosis occurred due to hematoma formation and insufficient dressing compression, but healing was achieved through dressing changes. Overall, patients showed improvements in flap color (from dark to ruddy), texture (softened), and skin tension (decreased), with visible wrinkle formation. Long-term follow-up confirmed satisfactory appearance and functional outcomes.
conclusionLocal injection of CGF effectively enhances flap survival by promoting recovery from IR injury. This strategy may offer a promising adjunctive therapy in reconstructive procedures to improve tissue viability and healing.
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