Evidence map›Paper›PMID 40265461›Full record

ArticleThoracic cancer2025

Chest Tube Drainage, Bone Radiotherapy, and Brain Radiotherapy in Advanced Lung Cancer: A Retrospective Analysis of Associated Factors and Survival.

Shoko Sonobe Shimamura, Takehito Shukuya, Kazuhisa Takahashi, Yasushi Shintani, Ikuo Sekine, Koichi Takayama, Akira Inoue, Isamu Okamoto, Tomoya Kawaguchi, Nobuyuki Yamamoto and 3 more

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Article in Thoracic cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shoko Sonobe ShimamuraDepartment of Respiratory Medicine, Juntendo University, Tokyo, Japan.
Takehito ShukuyaDepartment of Respiratory Medicine, Juntendo University, Tokyo, Japan.ORCID https://orcid.org/0000-0002-0972-4692
Kazuhisa TakahashiDepartment of Respiratory Medicine, Juntendo University, Tokyo, Japan.
Yasushi ShintaniDepartment of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Ikuo SekineDepartment of Medical Oncology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Koichi TakayamaDepartment of Pulmonary Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Akira InoueDepartment of Palliative Medicine, Tohoku University School of Medicine, Sendai, Miyagi, Japan.
Isamu OkamotoDepartment of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID https://orcid.org/0000-0002-7587-6096
Tomoya KawaguchiDepartment of Respiratory Medicine, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Nobuyuki YamamotoInternal Medicine III, Wakayama Medical University, Wakayama, Japan.
Etsuo MiyaokaDepartment of Mathematics, Tokyo University of Science, Tokyo, Japan.
Ichiro YoshinoDepartment of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hiroshi DateDepartment of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPalliative interventions, such as chest tube drainage and radiotherapy for bone and brain metastases, are crucial for managing survival and quality of life in patients with advanced lung cancer.

methodsThis retrospective study analyzed 8171 patients with unresectable Stage IV lung cancer from the Japanese Joint Committee of Lung Cancer Registry (JJCLCR) database. At treatment initiation, 8.6% of patients underwent chest tube drainage, 9.9% underwent bone radiotherapy, and 11.5% underwent brain radiotherapy. In this study, associated factors for palliative interventions were evaluated, and their impact on patient survival was also assessed.

resultsHigh-associated factors for upfront chest tube drainage included age ≥ 75 years, ECOG-PS ≥ 2, pleural nodules, and adenocarcinoma, while EGFR mutation, serum albumin ≥ 3.2 mg/dL, adrenal gland, and brain metastases were low-associated factors. For upfront brain radiotherapy, low-associated factors included malignant pleural effusion (MPE) and bone metastases, whereas ECOG-PS ≥ 2 was a high-associated factor. High-associated factors for upfront bone radiotherapy were serum albumin ≥ 3.2 mg/dL, ECOG-PS ≥ 2, adenocarcinoma, and squamous cell carcinoma, while pleural nodules, MPE, liver, and brain metastasis were low-associated factors. Patients receiving upfront bone radiotherapy had shorter survival, whereas survival did not significantly differ for those with or without upfront chest tube drainage or brain radiotherapy.

conclusionThis study identified associated factors for palliative interventions in advanced lung cancer and their association with overall survival. Future prospective studies with more detailed data are necessary to confirm these findings and improve clinical decision-making.

trial registrationApproval No. 15,321.

Indexed as

Bone NeoplasmsBrain NeoplasmsCranial IrradiationDrainageLung NeoplasmsAgedAged, 80 and overChest TubesFemaleHumansMaleMiddle AgedPalliative CareRetrospective Studiesassociated factorschest tube drainagelung cancerpalliative careradiotherapy

Identifiers

PMID40265461
PMCPMC12015636

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.