Congenital Melanocytic Nevus with Neurocristic Cutaneous Hamartoma: A Case Report.

Dina El-Rayes, Katlin Wilson, Sheilagh Maguiness, Daniel Miller, Gerardo Cazzato, Alessio Giubellino

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In one paragraph

Article in Dermatopathology (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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1 citing paper in PubMed.

Gene fusions in melanocytic lesions: an updated comprehensive review.Journal of pathology and translational medicine · 2026
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5 · Who and what money

Authors and funding

6 authors.

Dina El-RayesDepartment of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN 55455, USA.

Katlin WilsonDepartment of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0005-6461-8103

Sheilagh MaguinessDepartment of Dermatology, University of Minnesota, Minneapolis, MN 55455, USA.

Daniel MillerDepartment of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN 55455, USA.

Gerardo CazzatoSection of Molecular Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.ORCID 0000-0003-0325-4316

Alessio GiubellinoDepartment of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-5352-0662

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital melanocytic nevi (CMN) are benign tumors present at birth or arising in the first few months of life. A small subset of these nevi present with mild atypical features and heterogeneous differentiation, including Schwannian differentiation. We present a case of a 3-week-old with a 7 cm red/purple scalp nodule consistent with CMN with mild atypical heterogeneous areas. On histology, there were dermal nests of spindle cells in a fibrillar matrix, with increased vessels and clusters of small round melanocytes interspersed between collagen bundles and around adnexal structures. The lesion also exhibited rare pagetoid ascent of melanocytes as single cells and nests. Overall, these features were consistent with a CMN with nodular proliferative neurocristic cutaneous hamartoma (NCH) with a component of a compound mild atypical melanocytic proliferation. Next generation sequencing (NGS) identified a novel SH2B1::BRAF fusion. This case highlights the diagnostic challenges of heterogeneous differentiation within CMN in young children.

Indexed as

congenital melanocytic nevusnodular proliferative neurocristic cutaneous hamartomasSchwannian differentiation

Identifiers

PMID40265343

DOI10.3390/dermatopathology12020012

PMCPMC12015924

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