Evidence map›Paper›PMID 40265287›Full record

ArticleImmunology2025

Obesity-Induced Metabolic Priming Exacerbates SARS-CoV-2 Inflammation.

Gustavo Gastão Davanzo, Bianca Gazieri Castelucci, Gabriela Fabiano de Souza, Stéfanie Primon Muraro, Larissa Menezes Dos Reis, Isabella Bonilha de Oliveira, José Luís Fachi, João Victor Virgilio-da-Silva, Marcelo Rodrigues Berçot, Mariane Font Fernandes and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Gustavo Gastão DavanzoLaboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Bianca Gazieri CastelucciLaboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Gabriela Fabiano de SouzaLaboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Stéfanie Primon MuraroLaboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Larissa Menezes Dos ReisLaboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.ORCID 0000-0003-1597-0176
Isabella Bonilha de OliveiraDepartment of Clinical Medicine, School of Medical Sciences, University of Campinas, São Paulo, Brazil.
José Luís FachiLaboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
João Victor Virgilio-da-SilvaLaboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Marcelo Rodrigues BerçotLaboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Mariane Font FernandesLaboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Sarah de OliveiraLaboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Nathalia Vitoria Pereira AraujoLaboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Guilherme RibeiroLaboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Gisele de CastroLaboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Webster Leonardo Guimarães CostaLaboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Adriana Leandra SantoroLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), São Paulo, Brazil.
Gabriela Flavia Rodrigues-LuizLaboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Helison Rafael P do CarmoDepartment of Clinical Medicine, School of Medical Sciences, University of Campinas, São Paulo, Brazil.
Ikaro BrederDepartment of Clinical Medicine, School of Medical Sciences, University of Campinas, São Paulo, Brazil.
Marcelo A MoriObesity and Comorbidities Research Center (OCRC), University of Campinas, São Paulo, Brazil.
Alessandro S FariasExperimental Medicine Research Cluster (EMRC), University of Campinas, São Paulo, Brazil.
Daniel Martins-de-SouzaLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), São Paulo, Brazil.
Joseph W GuarnieriCenter for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Douglas C WallaceCenter for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Marco Aurélio Ramirez VinoloLaboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
José Luiz Proença-MódenaLaboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Afshin BeheshtiBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Andrei C SpositoLaboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
Pedro M Moraes-VieiraLaboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DOUGLAS J EPSTEIN · 1986 to 2026
$48.3M
Conselho Nacional de Desenvolvimento Científico e Tecnológico 406974/2023-3Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de São Paulo 13/07607-8Fundação de Amparo à Pesquisa do Estado de São Paulo 18/15313-8Fundação de Amparo à Pesquisa do Estado de São Paulo 20/04579-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/15626-8Fundação de Amparo à Pesquisa do Estado de São Paulo 20/16030-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/18031-8Fundação de Amparo à Pesquisa do Estado de São Paulo 21/08354-2Fundo de Apoio ao Ensino, à Pesquisa e Extensão, Universidade Estadual de Campinas 2274/20NIDDK NIH HHS P30 DK019525
6 · The paper itself

Abstract

Despite the early recognition that individuals living with obesity are more prone to develop adverse outcomes during COVID-19, the mechanisms underlying these conditions are still unclear. During obesity, an accumulation of free fatty acids (FFAs) in the circulation promotes low-grade inflammation. Here, we show that FFAs induce epigenetic reprogramming of monocytes, exacerbating their inflammatory profile after SARS-CoV-2 infection, a mechanism named metabolic-primed immunity. Monocytes from people with obesity or primed with palmitate, a central component of circulating FFAs, presented elevated viral load and higher gene expression of IL-6. Palmitate-primed monocytes upregulate fatty acid oxidation and FFAs entry into the mitochondria. FFA-derived acetyl-CoA is then converted into citrate, exiting the mitochondria and is used to support H3K18 histone acetylation, which regulates IL-6 accessibility. Ingestion of palm oil by lean and healthy individuals increased circulating FFAs levels and was sufficient to exacerbate the inflammatory profile of monocytes upon SARS-CoV-2 infection. Our findings demonstrate that obesity-derived FFAs induce the metabolic priming of monocytes, which exacerbates the inflammatory response observed in people with severe COVID-19.

Indexed as

COVID-19Fatty Acids, NonesterifiedInflammationMonocytesObesitySARS-CoV-2AdultFemaleHumansInterleukin-6MaleMiddle AgedMitochondriaViral LoadFatty Acids, NonesterifiedInterleukin-6COVID‐19inflammationinnate immunitymonocyteobesity

Identifiers

PMID40265287
PMCPMC12130675

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.