Evidence map›Paper›PMID 40265200›Full record

ArticleHistology and histopathology2025

Oroxin B prevented sepsis-evoked acute lung injury by promoting M2 macrophage polarization through the TLR4/NF-κB axis.

Chen Li, Jianhua Liu, Changhong Zhang, Feng Li, Nana Duan, Zhihua Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Histology and histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Scutellarein fromPharmaceuticals (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chen LiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou City, Hebei Province, China.
Jianhua LiuDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou City, Hebei Province, China.
Changhong ZhangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou City, Hebei Province, China.
Feng LiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou City, Hebei Province, China.
Nana DuanDepartment of Pharmacy, The First Affiliated Hospital of Hebei North University, Zhangjiakou City, Hebei Province, China.
Zhihua ZhangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou City, Hebei Province, China. zzh19641229@126.com.

Funding

Chinese Medicine Scientific Research Project, Ji Traditional Chinese Medicine 2023103
6 · The paper itself

Abstract

Acute lung injury (ALI) is a frequent complication of sepsis that aggravates sepsis mortality and morbidity, which is tightly related to the inflammatory process. Oroxin B (OB), a flavonoid from

Indexed as

Acute Lung InjuryFlavonoidsMacrophagesNF-kappa BSepsisToll-Like Receptor 4AnimalsDisease Models, AnimalMacrophage ActivationMaleMiceMice, Inbred C57BLRAW 264.7 CellsSignal TransductionFlavonoidsNF-kappa BTlr4 protein, mouseToll-Like Receptor 4

Identifiers

PMID40265200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.