Evidence map›Paper›PMID 40265169›Full record

ArticleHemaSphere2025

Orchestration of human multi-lineage hematopoietic cell development by humanized in vivo bone marrow models.

Laurent Renou, Wenjie Sun, Chloe Friedrich, Klaudia Galant, Cecile Conrad, Anne Consalus, Evelia Plantier, Katharina Schallmoser, Linda Krisch, Vilma Barroca and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HemaSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Laurent RenouUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LSHL/iRCM/IBFJ Fontenay-aux-Roses France.ORCID https://orcid.org/0009-0005-7793-8544
Wenjie SunInstitut Curie, Université PSL, Sorbonne Université, CNRS UMR168, Laboratoire Physico Chimie Curie Paris France.
Chloe FriedrichInstitut Cochin, CNRS UMR8104, INSERM U1016 Université Paris Cité Paris France.
Klaudia GalantUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LSHL/iRCM/IBFJ Fontenay-aux-Roses France.
Cecile ConradInstitut Curie, Université PSL, Sorbonne Université, CNRS UMR168, Laboratoire Physico Chimie Curie Paris France.
Anne ConsalusUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LSHL/iRCM/IBFJ Fontenay-aux-Roses France.
Evelia PlantierUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LSHL/iRCM/IBFJ Fontenay-aux-Roses France.
Katharina SchallmoserDepartment for Transfusion Medicine and GMP Unit Paracelsus Medical University Salzburg Austria.
Linda KrischDepartment for Transfusion Medicine and GMP Unit Paracelsus Medical University Salzburg Austria.
Vilma BarrocaUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LSHL/iRCM/IBFJ Fontenay-aux-Roses France.
Saryami DevanandUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LSHL/iRCM/IBFJ Fontenay-aux-Roses France.
Nathalie DechampsUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LSHL/iRCM/IBFJ Fontenay-aux-Roses France.
Andreas ReinischDepartment of Internal Medicine, Division of Hematology Medical University of Graz Graz Austria.
Jelena MartinovicFetal Pathology Unit AP-HP, Hôpital Antoine Beclère Clamart France.
Alessandra MagnaniBiotherapy Department Hôpital Necker-Enfants Malades Paris France.
Lionel FaivreCell Therapy Unit AP-HP, Saint Louis Hospital Paris France.
Daniel LewandowskiUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LSHL/iRCM/IBFJ Fontenay-aux-Roses France.
Julien CalvoUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LSHL/iRCM/IBFJ Fontenay-aux-Roses France.
Leila PerieInstitut Curie, Université PSL, Sorbonne Université, CNRS UMR168, Laboratoire Physico Chimie Curie Paris France.
Olivier KosmiderOPALE Carnot Institute, The Organization for Partnerships in Leukemia Paris France.
Françoise PflumioUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LSHL/iRCM/IBFJ Fontenay-aux-Roses France.ORCID 0000-0001-8995-596X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematopoiesis develops in the bone marrow (BM) where multiple interactions regulate the differentiation and preservation of hematopoietic stem and progenitor cells (HSPCs). Immune-deficient murine models have enabled the analysis of molecular and cellular regulation of human HSPCs, but the physiology of these models is questioned as human hematopoietic cells develop in xenogenic microenvironments. In this study, we thoroughly characterized a humanized (h) in vivo BM model, developed from fetal (F/) and post-natal (P-N/) mesenchymal stromal cell (MSC) differentiation (called hOssicles [hOss]), in which human hematopoietic cells are generated following the transplantation of CD34

Identifiers

PMID40265169
PMCPMC12012840

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.