Evidence map›Paper›PMID 40265103›Full record

ArticleBiomaterials research2025

Injectable Brain Extracellular Matrix Hydrogels Enhance Neuronal Migration and Functional Recovery After Intracerebral Hemorrhage.

Jiajie Xia, Xinjie Gao, Jun Yao, Yuchao Fei, Dagang Song, Zhiwei Gu, Gang Zheng, Yuxiang Gu, Chuanjian Tu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiajie XiaDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China.ORCID https://orcid.org/0000-0003-3225-0154
Xinjie GaoDepartment of Neurosurgery of Huashan Hospital, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Fudan University, Shanghai 200000, China.
Jun YaoDepartment of Orthopedic Surgery, Shaoxing Central Hospital, The Central Affiliated Hospital, Shaoxing University, Shaoxing, Zhejiang 312030, China.
Yuchao FeiDepartment of Neurosurgery of Huashan Hospital, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Fudan University, Shanghai 200000, China.
Dagang SongDepartment of Neurosurgery, Shaoxing Central Hospital, The Central Affiliated Hospital, Shaoxing University, Shaoxing, Zhejiang 312030, China.
Zhiwei GuDepartment of Neurosurgery, Shaoxing Central Hospital, The Central Affiliated Hospital, Shaoxing University, Shaoxing, Zhejiang 312030, China.
Gang ZhengDepartment of Neurosurgery, Shaoxing Central Hospital, The Central Affiliated Hospital, Shaoxing University, Shaoxing, Zhejiang 312030, China.
Yuxiang GuDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China.
Chuanjian TuDepartment of Neurosurgery, Shaoxing Central Hospital, China Medical University, Shaoxing, Zhejiang 312030, China.ORCID https://orcid.org/0009-0008-7157-5852

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural repair within the lesion cavity caused by intracerebral hemorrhage (ICH) remains a major therapeutic challenge. Hydrogels hold great potential in regenerative medicine as functional scaffolds. However, inadequate host cell infiltration and suboptimal delivery methods have limited their application in tissue engineering. Here, we describe an optimized decellularization approach to create injectable brain extracellular matrix (ECM) hydrogels for the treatment of ICH. The hydrogel exhibits excellent biodegradability and biocompatibility. In an ICH rat model, the hydrogel implanted into the stroke cavity promoted neural recovery, facilitated cell recruitment, enhanced angiogenesis, and inhibited inflammation in the peri-cavity region at 14 d post-implantation. Furthermore, the hydrogel improved cell proliferation and migration, reversed cell apoptosis, and modulated transcriptomic changes in vitro. Notably, the hydrogel may promote neuronal migration and neural functional recovery after ICH through the slit guidance ligand 2-receptor roundabout guidance receptor 1 (Slit2-Robo1) signaling pathway. These findings highlight the potential of brain ECM hydrogels as a promising strategy for brain tissue regeneration.

Identifiers

PMID40265103
PMCPMC12012376

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.