"Optic nerve of steel": A case of very high intraocular pressures with markedly little visual field progression over years.

Purpose: We report a case of pseudoexfoliation glaucoma with exceedingly high intraocular pressures (IOP) but limited visual field progression despite poor adherence with treatment over a 7-year period. Observation: A 67-year-old Eastern European female presented to the emergency room with an IOP of 52 mmHg OD and exam findings consistent with pseudoexfoliation glaucoma. Subsequent testing demonstrated superior and inferior arcuate deficits on Humphrey visual field (HVF) testing and corresponding thinning of optic nerve OD. The patient was very inconsistent with topical glaucoma medications, and after undergoing selective laser trabeculoplasty she was lost to follow-up without any additional treatment. She returned one year later with an IOP of 59 mmHg, but remarkably stable HVF. The patient refused to restart glaucoma drops and elected instead to proceed with a trabeculectomy OD, which was successfully performed, with the final visual acuity of 20/25 and IOP of 20 mmHg OD. The patient was again lost to follow-up for three years. Her IOP was 40 mmHg OD on return to clinic, but her glaucoma testing revealed very little progression. She decided to pursue placement of glaucoma drainage device (Baerveldt 350) OD, and her IOP was 18 mmHg OD after 6 months on no medications. The patient was lost to follow-up thereafter. Conclusions: The limited visual field progression with chronically high IOP over years strongly argues in favor of IOP-independent mechanisms contributing to pathophysiology of glaucoma. This case also highlights the importance of longitudinal monitoring and tailoring glaucoma therapy holistically to individual patient circumstances.