Evidence map›Paper›PMID 40265035›Full record

ArticleJournal of advanced periodontology & implant dentistry2025

Clinical effectiveness of aloe vera gel as an adjunct to mechanical debridement in patients with periodontitis: A systematic review and meta-analysis.

Nisha Ashifa, Krishnan Viswanathan, Sivapragasam Srinivasan, Varsha K Pavithran, Shiva Shankar, Rajasekar Sundaram, Senthil Kumar, Divvi Anusha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced periodontology & implant dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. International journal of dentistry · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nisha AshifaDepartment of Periodontology, Rajah Muthiah Dental College & Hospital, Annamalai University, Annamalai Nagar, Tamil Nadu, India.ORCID https://orcid.org/0000-0002-3554-293X
Krishnan ViswanathanDepartment of Periodontology, Rajah Muthiah Dental College & Hospital, Annamalai University, Annamalai Nagar, Tamil Nadu, India.ORCID https://orcid.org/0000-0003-1093-0060
Sivapragasam SrinivasanDepartment of Periodontology, Rajah Muthiah Dental College & Hospital, Annamalai University, Annamalai Nagar, Tamil Nadu, India.ORCID https://orcid.org/0000-0001-5344-8026
Varsha K PavithranPublic Health Researcher & Biostatistician, Rypple Foundation Cypresstraat 64, 2565LW Den Haag, India.ORCID https://orcid.org/0000-0003-3206-6330
Shiva ShankarDepartment of Public Health Dentistry, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth, Puducherry, India.ORCID https://orcid.org/0000-0002-6868-9639
Rajasekar SundaramDepartment of Periodontology, Rajah Muthiah Dental College & Hospital, Annamalai University, Annamalai Nagar, Tamil Nadu, India.ORCID https://orcid.org/0000-0001-7887-4574
Senthil KumarDepartment of Periodontology, Rajah Muthiah Dental College & Hospital, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
Divvi AnushaDepartment of Public Health Dentistry, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth, Puducherry, India.ORCID https://orcid.org/0000-0001-7024-4594

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aimed to evaluate the clinical effect of aloe vera gel as an adjunct to scaling and root planing (SRP) on plaque index (PI), gingival index (GI), and probing pocket depth (PPD) in periodontitis treatment. Methods: Randomized controlled trials (RCTs) were included, focusing on aloe vera gel as an adjunct to SRP in periodontitis patients. An extensive literature search was conducted across PubMed, PubMed Central, Scopus, OVID, Google Scholar, and Cochrane Library databases up to October 2024. The risk of bias was assessed using the Revised Cochrane Risk of Bias tool (ROB 2.0), and statistical analysis was performed using Review Manager 5.4.1. Results: Fifteen RCTs were included in this systematic review, and separate meta-analyses were conducted for each outcome. For PI, the random effects model showed a mean difference (MD) of -0.23 (95% CI: -0.69, 0.23), favoring the experimental group ( Conclusion: As an adjunct to SRP, aloe vera gel significantly improved PI, GI, and PPD in periodontitis patients. Trial registration: PROSPERO ID: CRD42020201315.

Indexed as

Aloe vera gelDental scalingMeta-analysisPeriodontitisRoot planingSystematic review

Identifiers

PMID40265035
PMCPMC12010479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.