Evidence map›Paper›PMID 40265032›Full record

ArticleJournal of advanced periodontology & implant dentistry2025

Salivary carcinoembryonic antigen in desquamative gingivitis: A comparative study in oral lichenoid reactions before and after topical corticosteroid therapy.

Ayla Bahramian, Farzaneh Pakdel, Solmaz Pourzare Mehrbani, Ehsan Golchin, Ensiyeh Maljaei, Maryam Hosseinpour Sarmadi, Tara Deljavanghodrati, Katayoun Katebi

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Article in Journal of advanced periodontology & implant dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ayla BahramianDepartment of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0003-1693-6420
Farzaneh PakdelDepartment of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0003-2656-8334
Solmaz Pourzare MehrbaniDepartment of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0001-8466-4450
Ehsan GolchinToxoplasmosis Research Center, Mazandaran University of Medical Science, Sari, Iran.ORCID https://orcid.org/0000-0003-4737-079X
Ensiyeh MaljaeiPrivate Practice, Tabriz, Iran.ORCID https://orcid.org/0000-0001-5672-0232
Maryam Hosseinpour SarmadiDepartment of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-2599-4553
Tara DeljavanghodratiDentistry Faculty of Yeditepe University, Istanbul, Turkey.ORCID https://orcid.org/0009-0006-1923-2495
Katayoun KatebiDepartment of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-6595-6359

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Desquamative gingivitis is an immunological chronic disease that is considered precancerous and has the potential to develop into squamous cell carcinoma. Carcinoembryonic antigen (CEA), a common tumor marker, increases in many cancers. The present study compared salivary CEA levels in desquamative gingivitis before and after topical corticosteroid therapy. Methods: This case‒control study was conducted in the Department of Oral and Maxillofacial Medicine, Tabriz Faculty of Dentistry. Twenty patients with desquamative gingivitis in oral lichen planus (OLP) background were selected as the case group, with 20 healthy individuals as the control group. Desquamative gingivitis lesions were confirmed with biopsies. Salivary samples were obtained from both groups. Second, salivary samples were collected from the case group after a course of topical corticosteroid therapy. Salivary CEA levels were measured by a monobind kit using the ELISA method. Independent and paired t-tests were used to analyze the data in SPSS 17. Results: Before treatment, CEA levels were significantly higher in the case group (174.06±95.55) than in the control group (55.66±41.26 ng/mL) ( Conclusion: This study demonstrated that CEA levels significantly decreased in patients with desquamative gingivitis associated with oral lichenoid reaction after receiving topical corticosteroid therapy.

Indexed as

Carcinoembryonic antigenOral lichenoid reactionsSaliva

Identifiers

PMID40265032
PMCPMC12010480

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.