ArticleFrontiers in veterinary science2025
Pharmacokinetics and stability of methoxyflavones from
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Assessment of sub-chronic toxicity and anti-aging effects of a solid self-microemulsifying drug delivery system ofPharmaceutical biology · 2026Article
- Transdermal delivery and anti-inflammatory efficacy of Mitragyna speciosa extract transdermal patch for local inflammation management: in vitro, ex vivo, and in vivo investigations.Drug delivery and translational research · 2026Article
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Authors and funding
4 authors.
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Abstract
Introduction: The present study aimed to characterize the pharmacokinetics and stability of methoxyflavones derived from Method: Twenty-seven male roosters were randomly divided into three groups and received KP extract at different doses of 100, 150, and 200 mg/kg of body weight. Plasma samples were prepared using acetonitrile, ethyl acetate, and a mixture of both to compare the optimal extraction efficiency. Plasma methoxyflavones concentrations were quantified using a validated HPLC method. Pharmacokinetic parameters were calculated using PKSolver. A seven-day stability study assessed methoxyflavones degradation in blood and plasma samples stored at -20°C. Results and discussion: The results showed that methoxyflavones were rapidly absorbed, reaching maximum plasma concentrations (C
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