ArticleNeuro-oncology advances
Heterogeneity of intracellular calcium signaling of glioblastoma cells depends on intratumoral location and migration state.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Cancer Neuroscience: Linking Neuronal Plasticity with Brain Tumor Growth and Resistance.Biology · 2026Review
- Beyond synapses non-synaptic neural microenvironment interactions remodel circuits and drive glioma progression.Frontiers in oncology · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Glioblastoma (GB), is an incurable brain tumor characterized by extreme malignancy and invasiveness, and the cellular mechanisms underlying such a severe phenotype are not completely understood. Although calcium (Ca Methods: In this study, we developed a stably transfected GL261 cell line that coexpresses a red fluorescent protein for actin cytoskeleton staining and the intracellular Ca Results: Our results showed that cells located at the tumor core are densely packed and rounded in shape, contrasting sharply with the polarized morphology observed in the peripheral cells. This anatomical heterogeneity corresponded to notable variations of the physiological phenotype: cells at the tumor core displayed low Ca Conclusions: These findings suggest that GB cells manifest activity patterns depending upon their spatial location within the tumor and that these correlate with their migration.
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