ArticleNeuro-oncology advances
Outcomes in patients with multiple sclerosis and solid organ cancers treated with immune checkpoint inhibitors.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Combining Pembrolizumab and Ofatumumab in Triple-Negative Breast Cancer and Multiple Sclerosis: A Case Report.Surgical case reports · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Multiple sclerosis (MS) patients are excluded from studies of immune checkpoint inhibitors (ICIs) due to concern for MS flare. This study aims to report the incidence of MS relapse, immune-related adverse events (irAEs), and cancer outcomes in MS patients with solid-organ malignancy treated with ICIs. Methods: In this retrospective study, MS patients who received ICIs at University Hospitals Seidman Cancer Center were identified electronically. Information on MS relapses, irAEs, and cancer outcomes after ICI initiation was collected and analyzed. Results: Twelve patients were included in the study, all of whom had inactive MS. No patient experienced MS relapse or new lesions on brain MRI after ICI initiation. Two patients (16.7%) had severe irAEs (grade ≥ 3), which was acute pneumonitis. No deaths were associated. The objective response rate was 50%. An additional year of age was associated with a 14.2% decrease in the risk of developing severe irAEs (hazard ratio (HR) = 0.858; 95% confidence interval (CI): 0.798-0.922; Conclusions: Our study suggests that ICIs could be safely used in patients with inactive MS with a low risk of MS relapse and comparable irAE risk with the general population. Although larger studies are needed for confirmation, the benefit of using ICIs to treat solid-organ malignancies might outweigh the risk of withholding treatment for this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.