Clinical Features and Prognostic Insights in Sinonasal Sarcomas: A 76-Case Single-Institution Experience.

Objective: This study analyzed the clinical characteristics, treatment outcomes, and prognostic factors of sinonasal sarcomas through a single-institution experience involving 76 cases over 27 years. Methods: A retrospective review was conducted on 76 patients diagnosed with sinonasal sarcoma at a tertiary medical center from 1995 to 2022. Data collected included demographic information, tumor characteristics, and treatment modalities. Survival outcomes were assessed using Kaplan-Meier analysis, and prognostic factors were identified through univariate and multivariate Cox proportional hazards models. Results: The cohort included 45 males and 31 females, with a mean age of 42.6 years. The most common presenting symptom was nasal obstruction (22%). Rhabdomyosarcoma was the most prevalent subtype, accounting for 27.6% of cases. The 5- and 10-year overall survival (OS) rates were 62% and 56%, while the disease-free survival (DFS) rates were 51% and 41%. Survival outcomes were significantly worse in patients aged ≥ 61 years ( Conclusions: The results showed that advanced age, smoking history, and neurovascular involvement were key contributors to reduced survival, with identified as a significant independent predictors of higher mortality risk. These findings offer critical insight into the therapeutic management of this rare malignancy. Level of Evidence: 4.