Evidence map›Paper›PMID 40264799›Full record

ArticleiScience2025

Synthesis of versatile neuromodulatory molecules by a gut microbial glutamate decarboxylase.

Pavani Dadi, Clint W Pauling, Abhishek Shrivastava, Dhara D Shah

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Pavani DadiBiodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ 85281, USA.
Clint W PaulingBiodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ 85281, USA.
Abhishek ShrivastavaBiodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ 85281, USA.
Dhara D ShahBiodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ 85281, USA.

Funding

Mechanistic investigation of bacterial type 9 secretion system machinery and its involvement in gut metabolism and immunomodulationR35GM147131 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Abhishek Shrivastava · 2022 to 2026
$2.0M
NIGMS NIH HHS R35 GM147131
6 · The paper itself

Abstract

Dysbiosis of the microbiome correlates with many neurological disorders, yet very little is known about the chemistry that controls the production of neuromodulatory molecules by gut microbes. Here, we found that an enzyme glutamate decarboxylase (

Indexed as

BiochemistryMicrobiologyMolecular neuroscience

Identifiers

PMID40264799
PMCPMC12013497

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.