Evidence map›Paper›PMID 40264638›Full record

ArticleHealth science reports2025

Balance Confidence and Falls in Individuals With Charcot-Marie-Tooth Disease: A Cross-Sectional Observational Study.

Kirsten M Anderson, Bopha Chrea, Riccardo Zuccarino, Michael E Shy, Jason M Wilken

Abstract read
In one paragraph

Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frequency and Circumstances of Falls Events in People Living With Spinal and Bulbar Muscular Atrophy: A Cross-Sectional Survey.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kirsten M AndersonDepartment of Physical Therapy and Rehabilitation Science, Carver College of Medicine University of Iowa Iowa City Iowa USA.ORCID 0000-0003-4282-5038
Bopha ChreaDepartment of Orthopedics and Rehabilitation, Carver College of Medicine University of Iowa Iowa City Iowa USA.ORCID 0000-0003-4328-9855
Riccardo ZuccarinoDepartment of Neurology, Carver College of Medicine University of Iowa Iowa City Iowa USA.
Michael E ShyDepartment of Neurology, Carver College of Medicine University of Iowa Iowa City Iowa USA.
Jason M WilkenDepartment of Physical Therapy and Rehabilitation Science, Carver College of Medicine University of Iowa Iowa City Iowa USA.ORCID 0000-0002-5556-7667

Funding

University of Iowa Institute for Clinical and Translational ScienceUM1TR004403 · NCATS · UNIVERSITY OF IOWA · PI Marlan R Hansen, Patricia Winokur · 2023 to 2026
$16.1M
NCATS NIH HHS UM1 TR004403
6 · The paper itself

Abstract

Background and Aims: Impaired balance and functional deficits are common in individuals with Charcot-Marie-Tooth disease (CMT). Many individuals with CMT use ankle foot orthoses (AFOs) to improve their balance and function. The aim of this study was to evaluate the fall frequency, perceived effect of AFOs on balance, and balance confidence of individuals with CMT who currently use AFOs. Methods: Three hundred and six individuals participated in this study. Questions related to fall frequency, questions about the perceived effect of AFOs on balance, and the Activities Specific Balance Confidence Scale were distributed to individuals with CMT via e-mail using a Patient Contact Registry. Results: Many participants reported falling in the preceding 24 h (14% of participants) or week (38% of participants). 78% of participants indicated their AFOs improve their balance. Participants reported decreased balance confidence across a range of activities, with highest confidence for level ground walking and standing tasks (> 60%), markedly decreased confidence when walking on stairs, slopes, or with external stimuli (40-55%), and poor confidence when walking on icy sidewalks, when bumped, or on unsteady surfaces (< 40%). Conclusions: The data presented here provides insight into the frequency of falls and balance confidence for individuals with CMT who use AFOs. The Activities Specific Balance Confidence Scale can be used as an assessment tool to identify CMT patients with low balance confidence who are at risk for falls. This information can be used to target patient education and tailor treatment plans and interventions to address challenging activities. Further, this study will help to focus future studies investigating the effects of AFO design on balance confidence and falls.

Indexed as

ankle foot orthosisbalanceCharcot–Marie–Tooth diseasefalls

Identifiers

PMID40264638
PMCPMC12012002

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.