Evidence map›Paper›PMID 40264581›Full record

ArticleActa naturae

Alterations in the Expression of Proprotein Convertase Genes in Human Esophagus Squamous Cell Carcinomas.

A A Komissarov, M V Zinovyeva, A V Sass, T V Vinogradova, S I Koshechkin, V V Demkin, I B Zborovskaya, S V Kostrov, I V Demidyuk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta naturae. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

A A KomissarovNational Research Centre "Kurchatov Institute", Moscow, 123182 Russian Federation.
M V ZinovyevaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, 117997 Russian Federation.
A V SassShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, 117997 Russian Federation.
T V VinogradovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, 117997 Russian Federation.
S I KoshechkinNational Research Centre "Kurchatov Institute", Moscow, 123182 Russian Federation.
V V DemkinNational Research Centre "Kurchatov Institute", Moscow, 123182 Russian Federation.
I B ZborovskayaN.N. Blokhin National Medical Research Center of Oncology, Moscow, 115478 Russian Federation.
S V KostrovNational Research Centre "Kurchatov Institute", Moscow, 123182 Russian Federation.
I V DemidyukNational Research Centre "Kurchatov Institute", Moscow, 123182 Russian Federation.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proprotein convertases (PCs) constitute an enzyme family that includes nine highly specific human subtilisin-like serine proteases. It is known that the PCs mRNA levels vary in tumors, and that these proteases are involved in carcinogenesis. Thus, PCs may be considered as potential markers for typing and predicting the course of the disease, as well as potential targets for therapy. We used quantitative real-time PCR to evaluate the expression levels of PC genes in the paired samples of tumor and adjacent normal tissues derived from 19 patients with esophageal squamous cell carcinomas. We observed a significant enrichment of

Indexed as

cancergene expressionproprotein convertasequantitative real-time PCRserine protease

Identifiers

PMID40264581
PMCPMC12011192

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.