Evidence map›Paper›PMID 40264576›Full record

ArticleMedComm2025

Integrating Multiplex Immunohistochemistry and Machine Learning for Glioma Subtyping and Prognosis Prediction.

Houshi Xu, Zhen Fan, Shan Jiang, Maoyuan Sun, Huihui Chai, Ruize Zhu, Xiaoyu Liu, Yue Wang, Jiawen Chen, Junji Wei and 2 more

Abstract read
In one paragraph

Article in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Houshi XuDepartment of Neurosurgery Huashan Hospital Shanghai Medical College Fudan University Shanghai China.ORCID https://orcid.org/0000-0002-2878-0913
Zhen FanDepartment of Neurosurgery Huashan Hospital Shanghai Medical College Fudan University Shanghai China.
Shan JiangDepartment of Neurosurgery Huashan Hospital Shanghai Medical College Fudan University Shanghai China.
Maoyuan SunDepartment of Neurosurgery Huashan Hospital Shanghai Medical College Fudan University Shanghai China.
Huihui ChaiDepartment of Neurosurgery Huashan Hospital Shanghai Medical College Fudan University Shanghai China.
Ruize ZhuDepartment of Neurosurgery Huashan Hospital Shanghai Medical College Fudan University Shanghai China.
Xiaoyu LiuDepartment of Neurosurgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.
Yue WangDepartment of Neurosurgery Huashan Hospital Shanghai Medical College Fudan University Shanghai China.
Jiawen ChenDepartment of Neurosurgery Huashan Hospital Shanghai Medical College Fudan University Shanghai China.
Junji WeiResearch Unit of New Technologies of Micro-Endoscopy Combination in Skull Base Surgery (2018RU008) Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.
Ying MaoDepartment of Neurosurgery Huashan Hospital Shanghai Medical College Fudan University Shanghai China.
Zhifeng ShiDepartment of Neurosurgery Huashan Hospital Shanghai Medical College Fudan University Shanghai China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma subtyping is crucial for treatment decisions, but traditional approaches often fail to capture tumor heterogeneity. This study proposes a novel framework integrating multiplex immunohistochemistry (mIHC) and machine learning for glioma subtyping and prognosis prediction. 185 patient samples from the Huashan hospital cohort were stained using a multi-label mIHC panel and analyzed with an AI-based auto-scanning system to calculate cell ratios and determine the proportion of positive tumor cells for various markers. Patients were divided into two cohorts (training:

Indexed as

gliomamachine learningmIHCmolecular subtypeprognosis

Identifiers

PMID40264576
PMCPMC12013734

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.