Evidence map›Paper›PMID 40264575›Full record

ArticleMedComm2025

Tripartite Motif Containing 65 Deficiency Confers Protection Against Acute Kidney Injury via Alleviating Voltage-Dependent Anion Channel 1-Mediated Mitochondrial Dysfunction.

Tao Chen, Yang Zhang, Liting Ding, Chenlu Xiong, Chao Mei, Sisi Wei, Ming Jiang, Yingjie Huang, Jianrong Chen, Tao Xie and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tao ChenDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang China.
Yang ZhangDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang China.
Liting DingThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Jiangxi Provincial Key Laboratory of Bioengineering Drugs, Institute of Translational Medicine, Jiangxi Medical College Nanchang University Nanchang China.
Chenlu XiongDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang China.
Chao MeiDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang China.
Sisi WeiDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang China.
Ming JiangDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang China.
Yingjie HuangDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang China.
Jianrong ChenDepartment of Endocrinology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang China.
Tao XieThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Jiangxi Provincial Key Laboratory of Bioengineering Drugs, Institute of Translational Medicine, Jiangxi Medical College Nanchang University Nanchang China.
Qing ZhuThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Jiangxi Provincial Key Laboratory of Bioengineering Drugs, Institute of Translational Medicine, Jiangxi Medical College Nanchang University Nanchang China.
Qi ZhangThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Jiangxi Provincial Key Laboratory of Bioengineering Drugs, Institute of Translational Medicine, Jiangxi Medical College Nanchang University Nanchang China.
Xuan HuangThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Jiangxi Provincial Key Laboratory of Bioengineering Drugs, Institute of Translational Medicine, Jiangxi Medical College Nanchang University Nanchang China.ORCID https://orcid.org/0000-0002-9708-2270
Shibiao ChenDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang China.
Yong LiDepartment of Anesthesiology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang China.ORCID https://orcid.org/0000-0002-4108-0989

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury (AKI) is a prevalent and serious clinical disease with a high incidence rate and significant health burden. The limited understanding of the complex pathological mechanisms has hindered the development of efficacious therapeutics. Tripartite motif containing 65 (TRIM65) has recently been identified as a key regulator of acute inflammation. However, its role in AKI remains unclear. The present study observed that TRIM65 expression was upregulated in AKI. Moreover, the knockout of the

Indexed as

acute kidney injury (AKI)mitochondrial dysfunctiontripartite motif containing 65 (TRIM65)ubiquitinationvoltage‐dependent anion channel 1 (VDAC1)

Identifiers

PMID40264575
PMCPMC12013732

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.