The association between skeletal muscle mass and all-cause mortality in acute exacerbation of chronic obstructive pulmonary disease.

Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) significantly impacts patient quality of life and prognosis. Skeletal muscle mass loss, a systemic manifestation of COPD, has garnered increasing attention, but its association with all-cause mortality in AECOPD remains unclear. This study aimed to quantitatively assess skeletal muscle mass in AECOPD patients using computed tomography and explore the association between muscle mass-related indices and all-cause mortality risk. Methods: A total of 319 patients were enrolled in this single-center retrospective cohort study. Muscle mass-related indices, including skeletal muscle area, mean muscle density, intermuscular fat density, intermuscular fat area, and skeletal muscle index (SMI), were considered as independent variables. All-cause mortality was considered as the dependent variable. Univariate and multivariate Cox regression, subgroup and sensitivity analyses, receiver operating characteristic curve (ROC), restricted cubic spline plot (RCS), and Kaplan-Meier survival curves were used to examine the association between these indices and all-cause mortality in AECOPD patients. Results: During a median follow-up of 14.63 (6.33, 21.13) months, the all-cause mortality was 113 (35.4%). Multivariate Cox regression revealed that, regardless of whether SMI was grouped based on the median of 26.08 or the cut-off point of 24.01, the low SMI group had a higher risk of all-cause mortality (HR: 0.495, 95% CI: 0.330-0.743, Conclusion: Among patients with AECOPD, higher levels of SMI are significantly associated with a lower risk of all-cause mortality, suggesting that SMI may have important prognostic value in the assessment of mortality risk in AECOPD patients.