Evidence map›Paper›PMID 40264550›Full record

ArticleFrontiers in nutrition2025

The association between serum uric acid and depression among U.S. National Health and Nutrition Examination Survey.

Hong He, Ping Li, Haokun Huang, Yanlin Zeng, Min Zhang, Zhibing Chen, Shiqi Huang, Fangfang Zeng, Hui Ge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hong He *Healthcare Outpatient Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Ping Li *Department of Plastic Surgery, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
Haokun HuangDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
Yanlin ZengHealthcare Outpatient Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Min ZhangHealthcare Outpatient Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhibing ChenSchool of Public Health, Sun Yat-sen University, Guangzhou, China.
Shiqi HuangDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
Fangfang ZengDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
Hui GeHealthcare Outpatient Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous studies have suggested that serum uric acid (UA) may influence depression through oxidative stress pathways, but with inconclusive results. This study aimed to investigate the association between serum UA levels and depression, as well as potential variations across demographic subgroups in the U.S. adult population. Methods: A cross-sectional analysis of 23,059 participants from NHANES (2013-2018) was conducted. Serum UA levels were classified into quartiles, and depression was measured using the Patient Health Questionnaire-9 (PHQ-9), with a score ≥ 10 indicating depression. Weighted logistic regression models were used to analyze the association between UA levels and depression, adjusting for demographic and clinical covariates. Subgroup analyses were performed to assess variations by sex, age, race/ethnicity, and other health-related factors. Results: Participants in the highest UA quartile had a lower prevalence of depression compared to those in the lowest quartile (13.9% vs. 16.2%, Conclusion: Higher serum UA levels were inversely associated with depression among U.S. adults, especially among races, participants with cardiovascular disease and older age. Further research is needed to confirm these findings and investigate potential underlying mechanisms.

Indexed as

a cross-sectional analysisdepressionNHANESsubgroup analysesuric acid

Identifiers

PMID40264550
PMCPMC12011595

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.