ArticleJournal of animal science and technology2025
Genome-wide association studies of the fatty acid composition of Korean native chicken breast meat.
Article in Journal of animal science and technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Using Integrated Microbiome-Metabolome-Genome Axis Data to Elucidate the Mechanism by Which Polyphenol Content in the Extract fromFoods (Basel, Switzerland) · 2026Article
- Kinglet in the Poultry Court of Russia: Whole-Genome Insights into Ancestry, Genetic Variability, Selection Footprints and Candidate Genes in a Unique Local Chicken Breed Relative to Other Bantam/Dwarf Breeds.Animals : an open access journal from MDPI · 2026Article
- Bovine Colostrum-Derived Extracellular Vesicles May Accelerate the Growth ofFood science of animal resources · 2025Article
- Dietary L-Methionine modulates the gut microbiota and improves the expression of tight junctions in an in vitro model of the chicken gastrointestinal tract.Animal microbiome · 2024Article
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Authors and funding
6 authors.
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Abstract
The fatty acid composition of meat, which affects both its quality and the consumer's health, is a complex trait influenced by genetic and environmental factors. Identification of the genes influencing the fatty acid composition of meat is very important for the selection and breeding of chickens with desirable and healthier fatty acid profiles. The objective of this study was to identify functional candidate genes for fatty acid profiles of the breast meat of the Korean native chicken-red-brown line (KNC-R) through genome-wide association studies. We genotyped 382 KNC-R chickens (190 males, 192 females) using the Illumina chicken 60K single nucleotide polymorphism (SNP) chip (Illumina, San Diego, CA, USA), and association tests were performed by mixed linear model in the Genome-wide Complex Trait Analysis (GCTA) software, based on mixed linear model analysis-leave-one-chromosome-out (MLMA-LOCO). We detected one SNP each on chromosomes 2 (rs13667281), 10 (rs14011157), and 22 (rs10731996) that were significantly (p < 0.05) associated with nervonic (C24:1), linoleic (C18:2), and eicosadienoic (C20:2) acids, respectively. We found 13 protein-coding genes related to lipid metabolism, including IGF2BP3, GPNMB, NPY, OSBPL3, IL6, NR2F2, GPAT4, NKX6-3, ANK1, SFRP1, ERLIN2, STAR, and PPP1R3E. Interestingly, two candidate genes (GPNMB and SFRP1) were reported to regulate the expression of genes known to be involved in fatty acid synthesis, such as the FASN, ACACA, ACLY, ELOVL, and SCD genes. Identification of functional candidate genes for fatty acid profiles might facilitate the selection and breeding of chickens with desirable and healthier fatty acids.
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