Evidence map›Paper›PMID 40264513›Full record

ArticleFrontiers in cardiovascular medicine2025

A holistic approach to managing cardio-kidney metabolic syndrome: insights and recommendations from the Italian perspective.

Massimo Iacoviello, Mauro Gori, Giuseppe Grandaliano, Roberto Minutolo, Dario Pitocco, Roberto Trevisan

Abstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Cardio-kidney-metabolic (CKM) framework: A nephrologist's perspective.Archives of endocrinology and metabolism · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Massimo IacovielloDepartment of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
Mauro GoriDivision of Cardiology, Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Giuseppe GrandalianoDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Roberto MinutoloUnit of Nephrology, Dept of Advanced Medical and Surgery Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Dario PitoccoDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Roberto TrevisanEndocrinology and Diabetes Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardio-kidney metabolic (CKM) syndrome represents a complex and circular interplay of cardiovascular, renal, and metabolic dysfunctions, significantly contributing to global morbidity and mortality. This expert opinion synthesizes insights from a panel of Italian specialists in cardiology, nephrology, and diabetology, advocating for a holistic and integrated framework for CKM management. The recommendations underline the critical need for early identification and stratification of CKM stages, fostering an interdisciplinary approach that bridges specialties and ensures comprehensive care. Emphasizing innovative pathways for collaboration, including dynamic referral protocols, telemedicine, and shared decision-making, the proposed strategies aim to overcome structural and organizational barriers in healthcare. By promoting a unified approach, the framework seeks to streamline CKM care, enhance communication among specialists, and improve the coordination of services. This holistic strategy represents a pivotal step toward mitigating disease progression, improving clinical outcomes, and enhancing the quality of life for patients with CKM syndrome.

Indexed as

cardio-kidney metabolic syndromecardio-renal metabolic syndromecardiovascularcardiovascular-kidney metabolic syndromechronic kidney diseaseCKM syndromeCRM syndromerenal and metabolic disorders

Identifiers

PMID40264513
PMCPMC12011791

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.