ArticleFrontiers in cardiovascular medicine2025
Peak myocardial work assessment to detect coronary ischemia during dobutamine stress echocardiography.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Global Myocardial Work-Derived Nomogram for Coronary Stenosis Assessment in Stable Coronary Artery Disease: Development and External Validation.Diagnostics (Basel, Switzerland) · 2026Article
- Multimodality Cardiovascular Imaging in Patients After Coronary Artery Bypass Grafting: Diagnosis and Risk Stratification.Diagnostics (Basel, Switzerland) · 2025Review
- Stress Echocardiography Revisited: Toward Improving Patient Selection and Clinical Decision-Making.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Advanced Echocardiographic Approaches for Assessing Cardiac Dysfunction in Chronic Kidney Disease: Current Techniques and Future Perspectives.Clinical interventions in aging · 2025Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Peak global myocardial work efficiency (GWE), a measure of peak global myocardial constructive to wasted work ratio, has been shown to discriminate coronary ischemia during treadmill stress echocardiography (SE). We wanted to assess additive utility of peak global longitudinal strain (GLS), global work index (GWI), and GWE in improving positive predictive value (PPV) of an abnormal dobutamine stress echocardiography (DSE) and calculate cost-savings by avoiding secondary tests. Methods: We prospectively enrolled patients with abnormal DSE who underwent secondary confirmatory tests to confirm significant CAD as our primary cohort, and measured baseline and peak GLS, GWI, and GWE. We also included a control group with normal DSE results and similar measurements. The cost of secondary testing was used to calculate potential savings. Results: Among the 45 patients (71% females, mean age 60 ± 12 yrs.), 9 had significant CAD, 11 had non-significant CAD, and 25 were controls (N). Patients with significant CAD had significantly lower peak GLS [-15 (-17, -12.5) vs. -20 (-22, -19.5)%, Conclusions: Incorporating peak GWE into standard DSE interpretation enhanced diagnostic accuracy and reduced the cost of downstream testing.
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