ArticleFrontiers in cardiovascular medicine2025
Four-dimensional flow magnetic resonance assessment of alcohol septal ablation for hypertrophic obstructive cardiomyopathy and surgical valve replacement for aortic valve stenosis.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Alcohol Septal Ablation in Hypertrophic Obstructive Cardiomyopathy: Long-Term Follow-Up of Deformations and Hemodynamics.Journal of magnetic resonance imaging : JMRI · 2026Article
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3 authors.
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Abstract
Background: Hypertrophic cardiomyopathy sometimes complicates left ventricular (LV) outflow tract obstruction. Alcohol septal ablation (ASA) is indicated for drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). Moreover, with an aging population, aortic valve stenosis (AS) is increasing, and surgical aortic valve replacement (SAVR) is indicated in these cases. Both AS and HOCM have stenosis at the exit of the LV and there is a difference in valvular and/or muscular stenosis. However, it is not clear how the release of stenosis affects blood flow. We investigate the influence of ASA and SAVR on blood flow using four-dimensional flow phase-contrast magnetic resonance imaging (4D flow MRI). Methods: In this single-center retrospective observational study, we evaluated the blood flow of eight patients (five patients with HOCM and three patients with AS) before and after the intervention using 4D flow MRI. Results: The LV-aortic pressure gradient (PG) significantly improved from 79.4 ± 3.9 to 23.0 ± 2.0 mmHg ( Conclusions: The release of valvular or muscular stenosis has different effects on intra-LV blood flow. ASA reduced TKE loss and 4D flow MRI is useful to evaluate the efficacy of therapeutic interventions.
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