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ArticleRespirology case reports2025

Successful Management of Steroid-Refractory Immune-Related Pneumonitis With Mycophenolate Mofetil: A Case Report.

Hiroaki Ota, Daichi Fujimoto, Yoshiki Negi, Takashi Murata, Mayuko Tokuda, Tomoki Higashiyama, Akio Tada, Toshiyuki Minami, Taiichiro Otsuki, Koji Mikami and 3 more

Abstract read
In one paragraph

Article in Respirology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hiroaki OtaDepartment of Respiratory Medicine and Hematology Hyogo Medical University Nishinomiya Hyogo Japan.
Daichi FujimotoDepartment of Respiratory Medicine and Hematology Hyogo Medical University Nishinomiya Hyogo Japan.
Yoshiki NegiDepartment of Respiratory Medicine and Hematology Hyogo Medical University Nishinomiya Hyogo Japan.
Takashi MurataDepartment of Respiratory Medicine and Hematology Hyogo Medical University Nishinomiya Hyogo Japan.
Mayuko TokudaDepartment of Respiratory Medicine and Hematology Hyogo Medical University Nishinomiya Hyogo Japan.
Tomoki HigashiyamaDepartment of Respiratory Medicine and Hematology Hyogo Medical University Nishinomiya Hyogo Japan.
Akio TadaDepartment of Respiratory Medicine and Hematology Hyogo Medical University Nishinomiya Hyogo Japan.
Toshiyuki MinamiDepartment of Respiratory Medicine and Hematology Hyogo Medical University Nishinomiya Hyogo Japan.
Taiichiro OtsukiDepartment of Respiratory Medicine and Hematology Hyogo Medical University Nishinomiya Hyogo Japan.ORCID https://orcid.org/0009-0004-1473-6892
Koji MikamiDepartment of Respiratory Medicine and Hematology Hyogo Medical University Nishinomiya Hyogo Japan.
Ryo TakahashiDepartment of Respiratory Medicine and Hematology Hyogo Medical University Nishinomiya Hyogo Japan.
Kozo KuribayashiDepartment of Respiratory Medicine and Hematology Hyogo Medical University Nishinomiya Hyogo Japan.
Takashi KijimaDepartment of Respiratory Medicine and Hematology Hyogo Medical University Nishinomiya Hyogo Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Steroid-refractory immune-related pneumonitis is a clinical challenge with limited evidence-based treatment strategies. Current guidelines recommend the use of immunosuppressants; however, the optimal type and dosage of these agents remain unclear. Herein, we report a case of steroid-refractory immune-related pneumonitis that was successfully treated with mycophenolate mofetil (MMF). The patient did not respond to high-dose steroid therapy as initial treatment but showed significant improvement in both subjective symptoms and imaging findings after the additional administration of MMF. Subsequent tapering of the MMF dose led to worsening imaging findings, which improved upon re-escalation of the MMF dose. This case highlights the potential efficacy of MMF for the treatment of steroid-refractory immune-related pneumonitis and provides valuable insights into the administration of MMF and its potential role in managing similar cases.

Indexed as

immune‐related pneumonitismycophenolate mofetilsteroid‐refractory pneumonitis

Identifiers

PMID40264491
PMCPMC12011993

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.