ArticleFrontiers in aging neuroscience2025
Evaluation of the efficacy of Tai Chi on the cognitive function of patients with mild cognitive dysfunction and research on its mechanism.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 5 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Exercise modalities in mild cognitive impairment: a systematic review and network meta-analysis of comparative effectiveness.Frontiers in aging neuroscience · 2026Pooled it
- Nonlinear dose-response of mind-body exercise in older adults with mild cognitive impairment: A systematic review and meta-analysis.PloS one · 2026Pooled it
- Effect of traditional Chinese medicine non-pharmacological interventions on cognitive function in patients with mild cognitive impairment: a systematic review and network meta-analysis.Frontiers in medicine · 2026Pooled it
- Effects of aerobic exercise interventions on cognitive function, sleep quality, and quality of life in older adults with mild cognitive impairment: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Effects of three aerobic exercise modalities (walking, running, and cycling) on circulating brain-derived neurotrophic factor in older adults: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Tai Chi for treating cancer-related fatigue: A meta-analysis of randomized controlled trials.World journal of methodology · 2026Article
- Effects of Regular Exercise on Peripheral Brain-Derived Neurotrophic Factor in Neurological and Non-Neurological Populations: A Meta-Analysis with Meta-Regression.Brain sciences · 2025Review
- The Results of a 12-Month Open-Label Follow-Up Study with MRI Monitoring of Patients with Parkinson's Disease After MRI-Guided FUS.Journal of clinical medicine · 2025Article
- Neural mechanisms and social support for mental health in old age by martial arts exercise.Frontiers in psychology · 2025Review
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Authors and funding
9 authors.
Funding
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Abstract
Introduction: Studies have revealed that Tai Chi can enhance cognitive functions among patients with mild cognitive impairment (MCI). However, the precise mechanisms underlying this improvement remain elusive. Methods: Consequently, we conducted a study involving 54 elderly inpatients with MCI residing in a combined medical and elderly care facility in Chengdu, who were randomly divided into three groups: a control group engaging in daily living activities, a Tai Chi group that performed Tai Chi exercises in addition to control group activities, and a walking group that undertook walking activities as a supplement to the control group regimen. The intervention period lasted for 24 weeks, comprising 12 weeks of exercise and an additional 12 weeks of follow-up. The Montreal Cognitive Assessment (MoCA), Trail Making Test-A (TMT-A), Auditory Verbal Learning Test (AVLT), and biochemical assessments (measuring brain-derived neurotrophic factor, BDNF, and platelet factor 4, PF4) were administered to investigate overall cognitive function, executive function, memory capacity, and changes in serum concentrations of BDNF and PF4 before, after, and during the follow-up period. Data were analyzed using IBM SPSS 26.0, with statistical methods encompassing descriptive analysis, ANOVA, rank-sum test, repeated measures ANOVA, and generalized estimating equations. Results: Our findings indicated that after 24 weeks of intervention, the Tai Chi group exhibited improvements in cognitive function, executive function, and memory compared to the control group. This enhancement may be attributed to an increased expression of serum BDNF. Discussion: In conclusion, our study underscores the potential of Tai Chi in ameliorating cognitive function among elderly patients with mild cognitive impairment, thereby offering significant implications for clinical prevention and treatment strategies targeting this condition.
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